Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PGK1 | P00558 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17255757 | 0.92 | L3MBTL1 (0.49) | L3MBTL1POLBPGK1NPSR1CYP2D6 | |
| SCHEMBL4930910 | 0.77 | ACHE (0.62) | L3MBTL1POLBNPSR1CYP2D6MEN1 | |
| SCHEMBL11808662 | 0.76 | CHRM2 (0.46) | L3MBTL1POLBALDH1A1KMT2AHTR1A | |
| SCHEMBL27982786 | 0.74 | TSHR (0.55) | L3MBTL1POLBALDH1A1HTR1AADRA1D | |
| SCHEMBL6930794 | 0.74 | DRD2 (0.66) | HTR6HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL15244521 | 0.74 | PGK1 (0.48) | L3MBTL1PGK1HTR6HTR1AADRA1D | |
| SCHEMBL12433870 | 0.73 | CHRM2 (0.51) | L3MBTL1POLBALDH1A1CYP1A2HTR1A | |
| SCHEMBL15786248 | 0.73 | ALDH1A1 (0.51) | L3MBTL1PGK1CYP2D6MEN1ALDH1A1 | |
| SCHEMBL6527607 | 0.72 | CYP2D6 (0.52) | POLBNPSR1CYP2D6MEN1ALDH1A1 | |
| SCHEMBL9132120 | 0.72 | SMN1; SMN2 (0.47) | L3MBTL1POLBALDH1A1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029543-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | Wyeth (US) | 2009-03-04 | — | — | EP | disclosed |
| WO-2007146376-A2 | SUBSTITUTED 3-CYANOPYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH (US) | 2007-12-21 | — | — | WO | disclosed |