Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073210 | 0.86 | CYP3A4 (0.46) | RAB9AALDH1A1MAPTTSHRNPC1 | |
| SCHEMBL1273081 | 0.86 | CYP3A4 (0.46) | RAB9AALDH1A1MAPTTSHRNPC1 | |
| SCHEMBL4379160 | 0.83 | FDPS (0.46) | FDPSALDH1A1MAPTKDM4E | |
| SCHEMBL4773478 | 0.82 | LMNA (0.41) | RAB9AALDH1A1POLBNPC1KMT2A | |
| SCHEMBL4583741 | 0.79 | MMP1 (0.43) | RAB9APOLBKDM4EPTPRBNPC1 | |
| SCHEMBL1932047 | 0.79 | RAB9A (0.49) | RAB9AGAAFDPSALDH1A1MAPT | |
| SCHEMBL3958834 | 0.77 | OPRM1 (0.41) | RAB9APOLBTDP1NPC1KMT2A | |
| SCHEMBL3722221 | 0.75 | RIPK1 (0.40) | ALDH1A1MAPTPOLBTDP1KDM4E | |
| SCHEMBL1539491 | 0.74 | VNN1 (0.42) | RAB9APOLBKMT2AMEN1 | |
| SCHEMBL3960044 | 0.74 | RIPK1 (0.41) | RAB9AALDH1A1NPC1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874768-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113837-A2 | INHIBITORS OF AKT ACTIVITY | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | disclosed |