Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.41 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.41 |
| ▸ | CTBP2 | P56545 | 1/20 | 0.40 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CTSV | O60911 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1273081 | 0.84 | CYP3A4 (0.46) | RIPK1KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL4073210 | 0.84 | CYP3A4 (0.46) | RIPK1KMT2AALDH1A1MEN1SMN1; SMN2 | |
| SCHEMBL1539491 | 0.84 | VNN1 (0.42) | RIPK1KMT2AMEN1CTSSCTSK | |
| SCHEMBL3950927 | 0.82 | MEN1 (0.46) | KMT2AALDH1A1MEN1 | |
| SCHEMBL3722221 | 0.80 | RIPK1 (0.40) | RIPK1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL3953353 | 0.78 | GGPS1 (0.44) | KMT2AALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL4379160 | 0.76 | FDPS (0.46) | RIPK1ALDH1A1 | |
| SCHEMBL4773478 | 0.74 | LMNA (0.41) | KMT2AALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL4594149 | 0.74 | RAB9A (0.43) | KMT2AALDH1A1MEN1SMN1; SMN2NPC1 | |
| SCHEMBL5752814 | 0.74 | SLC6A2 (0.42) | RIPK1SHMT1SHMT2CTBP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009032653-A1 | INHIBITORS OF AKT ACTIVITY | SMITH KLINE BEECHAM CORPORATION (US) | 2009-03-12 | — | — | WO | disclosed |