SCHEMBL4073531

SCHEMBL4073531

N#CSC(C=O)c1ccc(F)cc1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
ALDH1A1 P00352 4/20 0.39
ALPG P10696 2/20 0.39
HPGD P15428 2/20 0.35
USP2 O75604 1/20 0.35
HTT P42858 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
TDP1 Q9NUW8 1/20 0.34
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23628847 0.95 LMNA (0.36) LMNASMN1; SMN2ALDH1A1ALPGHPGD
SCHEMBL3633293 0.81 HSD17B10 (0.34) LMNAALDH1A1HPGDTDP1HDAC4
SCHEMBL23628841 0.81 TSHR (0.38) LMNASMN1; SMN2ALDH1A1HPGDUSP2
SCHEMBL2494300 0.81 KIF11 (0.37)
SCHEMBL3974300 0.77 S1PR3 (0.35)
SCHEMBL8053155 0.71 LMNA (0.38) LMNASMN1; SMN2ALDH1A1ALPGHPGD
SCHEMBL2550741 0.71 LMNA (0.46) LMNASMN1; SMN2ALDH1A1ALPGHPGD
SCHEMBL23628844 0.67 DPP4 (0.37)
SCHEMBL8487888 0.67 ATM (0.43) LMNASMN1; SMN2ALDH1A1NPSR1TDP1
Water SCHEMBL28682098 0.67 LMNA (0.35) LMNASMN1; SMN2ALDH1A1ALPGHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1771177-A4 PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2009-07-29 EP disclosed
EP-1761268-A4 PYRROLOTRIAZINE KINASE INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2009-07-08 EP disclosed
EP-1771177-A2 PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2007-04-11 EP disclosed
EP-1768983-A2 FUSED HETEROCYCLIC KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2007-04-04 EP disclosed
EP-1761268-A2 PYRROLOTRIAZINE KINASE INHIBITORS Bristol-Myers Squibb Company (US) 2007-03-14 EP disclosed
WO-2006004884-A2 PROCESSES AND INTERMEDIATES USEFUL FOR PREPARING FUSED HETEROCYCLIC KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-01-12 WO disclosed
WO-2006004636-A2 FUSED HETEROCYCLIC KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-01-12 WO disclosed
WO-2006004833-A2 PYRROLOTRIAZINE KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2006-01-12 WO disclosed