Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GPX4 | P36969 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.32 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.32 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4073531 | 0.81 | LMNA (0.39) | ALDH1A1TDP1LMNAHPGDHDAC4 | |
| SCHEMBL23628841 | 0.81 | TSHR (0.38) | ALDH1A1TSHRMAPK1L3MBTL1LMNA | |
| SCHEMBL4068170 | 0.81 | TSHR (0.38) | ALDH1A1TSHRMAPK1L3MBTL1LMNA | |
| SCHEMBL2494300 | 0.77 | KIF11 (0.37) | CYP19A1 | |
| SCHEMBL23628847 | 0.77 | LMNA (0.36) | ALDH1A1TDP1LMNAHPGD | |
| SCHEMBL3974300 | 0.77 | S1PR3 (0.35) | — | |
| SCHEMBL3119634 | 0.75 | ADRB2 (0.40) | HSD17B10TSHRMAPK1HIF1ATDP1 | |
| SCHEMBL15210905 | 0.74 | KDM4E (0.36) | HSD17B10ALDH1A1TSHRMAPK1HIF1A | |
| SCHEMBL2542920 | 0.71 | ALDH1A1 (0.40) | HSD17B10ALDH1A1TSHRMAPK1HIF1A | |
| SCHEMBL8491351 | 0.67 | TRPA1 (0.43) | HSD17B10ALDH1A1TSHRMAPK1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155740-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. Hoffmann-Roche AG (CH) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008138753-A1 | HETARYLANILINES AS MODULATORS FOR AMYLOID BETA | F. HOFFMANN-LA ROCHE AG (CH) | 2008-11-20 | — | — | WO | disclosed |