Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.59 |
| ▸ | TGM2 | P21980 | 1/20 | 0.55 |
| ▸ | KRAS | P01116 | 5/20 | 0.54 |
| ▸ | HINT1 | P49773 | 1/20 | 0.52 |
| ▸ | IMPDH2 | P12268 | 5/20 | 0.51 |
| ▸ | STING1 | Q86WV6 | 2/20 | 0.51 |
| ▸ | IMPDH1 | P20839 | 2/20 | 0.51 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.51 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.51 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.49 |
| ▸ | PNP | P00491 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL401415 | 0.93 | TGM2 (0.56) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL5861503 | 0.90 | NT5E (0.60) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL4081026 | 0.90 | NT5E (0.60) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL1527362 | 0.89 | NT5E (0.59) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL19183426 | 0.87 | NT5E (0.57) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL4651242 | 0.86 | NT5E (0.56) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL2424287 | 0.85 | HINT1 (0.55) | NT5ETGM2KRASHINT1STING1 | |
| SCHEMBL18640378 | 0.85 | NT5E (0.57) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL22636005 | 0.84 | NT5E (0.62) | NT5ETGM2KRASHINT1IMPDH2 | |
| SCHEMBL22498538 | 0.84 | NT5E (0.62) | NT5ETGM2KRASHINT1IMPDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907590-B1 | T7 RNA POLYMERASE AND METHODS FOR THE GENERATION OF FULLY 2'-MODIFIED NUCLEIC ACID TRANSCRIPTS | ARCHEMIX LLC (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2207891-B1 | MATERIALS AND METHODS FOR THE GENERATION OF TRANSCRIPTS COMPRISING MODIFIED NUCLEOTIDES | ARCHEMIX LLC (US) | 2012-07-25 | — | — | EP | disclosed |
| US-8105813-B2 | Materials and methods for the generation of fully 2′-modified nucleic acid transcripts | ARCHEMIX CORP. (US) | 2012-01-31 | — | — | US | disclosed |
| US-8101385-B2 | Materials and methods for the generation of transcripts comprising modified nucleotides | ARCHEMIX CORP. (US) | 2012-01-24 | — | — | US | disclosed |
| EP-2207891-A2 | MATERIALS AND METHODS FOR THE GENERATION OF TRANSCRIPTS COMPRISING MODIFIED NUCLEOTIDES | Archemix Corp. (US) | 2010-07-21 | — | — | EP | disclosed |
| US-20100120024-A1 | Materials and methods for the generation of transcripts comprising modified nucleotides | ARCHEMIX CORP. | 2010-05-13 | — | — | US | disclosed |
| WO-2008078180-A2 | MATERIALS AND METHODS FOR THE GENERATION OF TRANSCRIPTS COMPRISING MODIFIED NUCLEOTIDES | ARCHEMIX CORP. (US) | 2008-07-03 | — | — | WO | disclosed |
| EP-1907590-A2 | MATERIALS AND METHODS FOR THE GENERATION OF FULLY 2'-MODIFIED NUCLEIC ACID TRANSCRIPTS | Archemix Corp. (US) | 2008-04-09 | — | — | EP | disclosed |
| US-20070117112-A1 | Materials and methods for the generation of fully 2'-modified nucleic acid transcripts | ARCHEMIX CORP. | 2007-05-24 | — | — | US | disclosed |
| WO-2007005645-A2 | MATERIALS AND METHODS FOR THE GENERATION OF FULLY 2'-MODIFIED NUCLEIC ACID TRANSCRIPTS | ARCHEMIX CORP. (US) | 2007-01-11 | — | — | WO | disclosed |