Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1F | O60840 | 1/20 | 0.42 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.42 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.42 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956220 | 0.84 | GABRA5 (0.46) | CACNA1FCACNA1DCACNA1SCACNA1CGABRA5 | |
| SCHEMBL6208345 | 0.81 | ADORA3 (0.41) | ADORA3KDM4ETSHRSMN1; SMN2GAA | |
| SCHEMBL6208783 | 0.80 | ADORA3 (0.42) | ADORA3KDM4ESMN1; SMN2GAAALDH1A1 | |
| SCHEMBL6207945 | 0.77 | TDP1 (0.34) | KDM4ETSHRPOLBALOX15SMN1; SMN2 | |
| SCHEMBL4075384 | 0.76 | ALOX5 (0.44) | CACNA1FCACNA1DCACNA1SCACNA1CGABRA5 | |
| SCHEMBL6208296 | 0.74 | GRM5 (0.45) | KDM4EPOLBSMN1; SMN2MEN1KMT2A | |
| SCHEMBL6207660 | 0.72 | GRM5 (0.43) | SMN1; SMN2KMT2A | |
| SCHEMBL6209016 | 0.72 | GRM5 (0.43) | L3MBTL1 | |
| SCHEMBL6209784 | 0.72 | GABRA2 (0.37) | TSHRPOLBMAPK1L3MBTL1SMN1; SMN2 | |
| SCHEMBL6208213 | 0.72 | GRM5 (0.43) | KDM4ETSHRKMT2AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029559-B1 | ARYL-4-ETHYNYL-ISOXAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2009-08-05 | — | — | EP | claimed |