Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | BACE1 | P56817 | 4/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 4/20 | 0.36 |
| ▸ | GRK6 | P43250 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755372 | 0.82 | TSHR (0.39) | MAPT | |
| SCHEMBL3396115 | 0.78 | GPR35 (0.41) | MAPT | |
| SCHEMBL3392997 | 0.72 | TDP1 (0.40) | MAPTACHE | |
| SCHEMBL4758286 | 0.70 | TSHR (0.36) | MAPT | |
| SCHEMBL4756152 | 0.67 | LMNA (0.33) | NPSR1 | |
| SCHEMBL4755316 | 0.67 | HCAR2 (0.36) | — | |
| SCHEMBL4758299 | 0.67 | LMNA (0.42) | BACE1HCAR3 | |
| SCHEMBL1371283 | 0.67 | MAPT (0.57) | MAPTNPSR1PTGS2BACE1HCAR3 | |
| Hydrochloric Acid SCHEMBL1890620 | 0.66 | MAPT (0.56) | MAPTNPSR1PTGS2BACE1HCAR3 | |
| SCHEMBL10874214 | 0.65 | TDP1 (0.38) | MAPTNPSR1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |