SCHEMBL4758286

SCHEMBL4758286

CCN1C(C)=C(C(=O)O)C(CC)(c2ccc(Cl)cc2Cl)C(C(=O)O)=C1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.36
CASP1 P29466 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
NOTUM Q6P988 2/20 0.36
MARS1 P56192 1/20 0.36
LMNA P02545 3/20 0.35
ALDH1A1 P00352 3/20 0.35
MAPT P10636 2/20 0.35
CYP3A4 P08684 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
HCAR2 Q8TDS4 1/20 0.34
MYC P01106 2/20 0.33
NR4A1 P22736 1/20 0.33
TP53 P04637 1/20 0.33
CRHBP P24387 1/20 0.33
CRHR2 Q13324 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
HTT P42858 1/20 0.33
MRGPRX4 Q96LA9 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4757320 0.90 HCAR2 (0.39) TSHRCASP1SMN1; SMN2NOTUMMARS1
SCHEMBL5533759 0.85 KDM4E (0.39) TSHRSMN1; SMN2LMNAALDH1A1MAPT
SCHEMBL4757355 0.84 PYGM (0.39) NOTUMLMNAALDH1A1CRHBPCRHR2
SCHEMBL4757333 0.81 OPRM1 (0.36) TSHRSMN1; SMN2NOTUMALDH1A1
SCHEMBL4758577 0.80 TSHR (0.36) TSHRNOTUMLMNAALDH1A1MAPT
SCHEMBL4758254 0.80 HCAR3 (0.39) TSHRSMN1; SMN2NOTUMLMNAALDH1A1
SCHEMBL4758583 0.79 PYGL (0.38) TSHRNOTUMLMNAALDH1A1MAPT
SCHEMBL4757340 0.79 NOTUM (0.34) NOTUML3MBTL1
SCHEMBL4758575 0.78 OPRM1 (0.39) TSHRNOTUMSLC6A4SLC6A3
SCHEMBL4939279 0.77 PTGDR2 (0.37) TSHRCASP1SMN1; SMN2NOTUMLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008006070-A2 COMPOUNDS AND COMBINATIONS THEREOF FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF USE THEREOF ROSKAMP RESEARCH LLC (US) 2008-01-10 WO disclosed
EP-1858325-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS Roskamp Research LLC (US) 2007-11-28 EP disclosed
WO-2006074419-A2 COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION AND METHODS OF IDENTIFYING THE COMPOUNDS ROSKAMP RESEARCH LLC (US) 2006-07-13 WO disclosed