SCHEMBL408142

SCHEMBL408142

COc1cccc(-c2cccc(C(=O)NC3CCN(P(=O)(OCC(C)(C)C)C(C)(C)C)CC3)c2)c1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.51
TSHR P16473 1/20 0.51
HPGDS O60760 1/20 0.50
MCHR1 Q99705 4/20 0.49
LMNA P02545 2/20 0.47
CCR3 P51677 1/20 0.47
DRD4 P21917 1/20 0.47
USP2 O75604 1/20 0.45
POLB P06746 1/20 0.45
MAPT P10636 3/20 0.45
HTT P42858 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
HSD17B10 Q99714 1/20 0.45
USP30 Q70CQ3 1/20 0.44
THRB P10828 1/20 0.44
RXFP1 Q9HBX9 1/20 0.44
KMT2A Q03164 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL408161 0.95 MCHR1 (0.46) ALDH1A1TSHRHPGDSMCHR1LMNA
SCHEMBL409337 0.94 MAPK1 (0.48) ALDH1A1TSHRHPGDSMCHR1LMNA
SCHEMBL408989 0.91 USP30 (0.54) ALDH1A1MCHR1DRD4SMN1; SMN2USP30
SCHEMBL18993556 0.90 TAS1R3 (0.47) ALDH1A1TSHRHPGDSMCHR1CCR3
SCHEMBL23347872 0.89 ALDH1A1 (0.45) ALDH1A1TSHRHPGDSMCHR1LMNA
SCHEMBL408148 0.87 USP30 (0.44) MCHR1DRD4USP30KMT2A
SCHEMBL18993477 0.86 DRD4 (0.49) HPGDSMCHR1DRD4USP30
SCHEMBL23347871 0.85 MCHR1 (0.46) ALDH1A1TSHRHPGDSMCHR1LMNA
SCHEMBL409841 0.85 USP2 (0.42) ALDH1A1TSHRMCHR1USP2POLB
SCHEMBL23344663 0.85 MCHR1 (0.44) ALDH1A1TSHRHPGDSMCHR1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11732259-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2018-04-05 US disclosed
US-9862946-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2018-01-09 US disclosed
US-9833468-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2017-12-05 US disclosed
US-20170198287-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2017-07-13 US disclosed
US-9682097-B2 Oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2017-06-20 US disclosed
US-20170051278-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. 2017-02-23 US disclosed
US-9469664-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2016-10-18 US disclosed
US-20160237426-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2016-08-18 US disclosed
US-9326992-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2016-05-03 US disclosed
US-20160102307-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2016-04-14 US disclosed
US-9161948-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2015-10-20 US disclosed
US-9066967-B2 Oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2015-06-30 US disclosed
US-20150073140-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS SAREPTA THERAPEUTICS, INC. (US) 2015-03-12 US disclosed
US-8779128-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2014-07-15 US disclosed
US-20140024698-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. (US) 2014-01-23 US disclosed
US-20140024821-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. (US) 2014-01-23 US disclosed
US-20120289457-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES AVI BIOPHARMA, INC. (US) 2012-11-15 US disclosed
US-20120065169-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2012-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120065169-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB ALDH1A1 2803/4885TSHR 2993/4885HPGDS 1795/4885
US-20160102307-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNB2, LMNA, LMNB1 ALDH1A1 4394/4885TSHR 1863/4885HPGDS 1248/4885
US-20150073140-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB ALDH1A1 2803/4885TSHR 2993/4885HPGDS 1795/4885
US-20140024698-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNA, LMNB2, LMNB1 ALDH1A1 4254/4885TSHR 3728/4885HPGDS 673/4885
US-20160237426-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES SNRPE, SMN1; SMN2, UPF1 ALDH1A1 3700/4885TSHR 721/4885HPGDS 1246/4885
US-20120289457-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES SNRPE, SMN1; SMN2, UPF1 ALDH1A1 3700/4885TSHR 721/4885HPGDS 1246/4885
US-20170051278-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNA, LMNB2, LMNB1 ALDH1A1 4254/4885TSHR 3728/4885HPGDS 673/4885
US-11732259-B2 Peptide oligonucleotide conjugates SNRPE, SMN1; SMN2, UPF1 ALDH1A1 3700/4885TSHR 721/4885HPGDS 1246/4885
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNB2, LMNA, LMNB1 ALDH1A1 4394/4885TSHR 1863/4885HPGDS 1248/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.