SCHEMBL409841

SCHEMBL409841

COc1cccc(-c2cccc(C(=O)NC3CCN(P(=O)(OCC(C)(C)C)C(C)(C)C)CC3)c2)c1OC

nearest known ligand 0.42

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.42
POLB P06746 1/20 0.42
ALDH1A1 P00352 3/20 0.42
HTR7 P34969 3/20 0.42
HTR1A P08908 1/20 0.42
SSTR5 P35346 2/20 0.42
SLC6A12 P48065 1/20 0.41
HTT P42858 1/20 0.41
MAPK10 P53779 1/20 0.41
DRD3 P35462 1/20 0.40
USP30 Q70CQ3 1/20 0.40
ERN1 O75460 1/20 0.40
STIM1 Q13586 1/20 0.40
ORAI1 Q96D31 1/20 0.40
RAB9A P51151 1/20 0.39
MCHR1 Q99705 2/20 0.39
TSHR P16473 1/20 0.39
ROCK2 O75116 1/20 0.39
ROCK1 Q13464 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23347862 0.94 USP2 (0.41) USP2POLBALDH1A1HTR7HTR1A
SCHEMBL21316779 0.91 USP2 (0.43) USP2POLBALDH1A1HTR7HTR1A
SCHEMBL22001602 0.89 USP2 (0.42) USP2POLBALDH1A1HTR7HTR1A
SCHEMBL408142 0.85 ALDH1A1 (0.51) USP2POLBALDH1A1HTTUSP30
SCHEMBL408989 0.85 USP30 (0.54) ALDH1A1HTR7HTR1AUSP30RAB9A
SCHEMBL409337 0.84 MAPK1 (0.48) ALDH1A1USP30RAB9AMCHR1TSHR
SCHEMBL408161 0.84 MCHR1 (0.46) POLBALDH1A1USP30ERN1MCHR1
SCHEMBL16209774 0.84 HTR7 (0.47) USP2POLBALDH1A1HTR7HTR1A
SCHEMBL409810 0.83 MCHR1 (0.50) POLBALDH1A1SSTR5MAPK10MCHR1
SCHEMBL14655016 0.83 USP2 (0.45) USP2POLBALDH1A1HTR7HTR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11732259-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2023-08-22 US disclosed
US-20210139897-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS SAREPTA THERAPEUTICS, INC. 2021-05-13 US disclosed
US-10760078-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2020-09-01 US disclosed
US-10398721-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2019-09-03 US disclosed
US-20190218551-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2019-07-18 US disclosed
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2018-04-05 US disclosed
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2018-04-05 US disclosed
US-9862946-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2018-01-09 US disclosed
US-9833468-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2017-12-05 US disclosed
US-20170198287-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2017-07-13 US disclosed
US-9326992-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2016-05-03 US disclosed
US-20160102307-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2016-04-14 US disclosed
US-9161948-B2 Peptide oligonucleotide conjugates SAREPTA THERAPEUTICS, INC. (US) 2015-10-20 US disclosed
US-9066967-B2 Oligonucleotide analogues targeting human LMNA SAREPTA THERAPEUTICS, INC. (US) 2015-06-30 US disclosed
US-20150073140-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS SAREPTA THERAPEUTICS, INC. (US) 2015-03-12 US disclosed
US-8779128-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups SAREPTA THERAPEUTICS, INC. (US) 2014-07-15 US disclosed
US-20140024698-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. (US) 2014-01-23 US disclosed
US-20140024821-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA SAREPTA THERAPEUTICS, INC. (US) 2014-01-23 US disclosed
US-20120289457-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES AVI BIOPHARMA, INC. (US) 2012-11-15 US disclosed
US-20120065169-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS JPMORGAN CHASE BANK, N.A. AS ADMINISTRATIVE AGENT 2012-03-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190218551-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB USP2 834/4885POLB 208/4885ALDH1A1 2803/4885
US-20120065169-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB USP2 834/4885POLB 208/4885ALDH1A1 2803/4885
US-10398721-B2 Methods for treating progeroid laminopathies using oligonucleotide analogues targeting human LMNA LMNA, LMNB2, LMNB1 USP2 4045/4885POLB 54/4885ALDH1A1 4254/4885
US-20160102307-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNB2, LMNA, LMNB1 USP2 4607/4885POLB 145/4885ALDH1A1 4394/4885
US-10760078-B2 Oligonucleotide analogues having modified intersubunit linkages and/or terminal groups NSUN2, UPF1, RTCB USP2 834/4885POLB 208/4885ALDH1A1 2803/4885
US-20150073140-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB USP2 834/4885POLB 208/4885ALDH1A1 2803/4885
US-20140024698-A1 METHODS FOR TREATING PROGEROID LAMINOPATHIES USING OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNA, LMNB2, LMNB1 USP2 4045/4885POLB 54/4885ALDH1A1 4254/4885
US-20210139897-A1 OLIGONUCLEOTIDE ANALOGUES HAVING MODIFIED INTERSUBUNIT LINKAGES AND/OR TERMINAL GROUPS NSUN2, UPF1, RTCB USP2 834/4885POLB 208/4885ALDH1A1 2803/4885
US-20120289457-A1 PEPTIDE OLIGONUCLEOTIDE CONJUGATES SNRPE, SMN1; SMN2, UPF1 USP2 2844/4885POLB 202/4885ALDH1A1 3700/4885
US-11732259-B2 Peptide oligonucleotide conjugates SNRPE, SMN1; SMN2, UPF1 USP2 2844/4885POLB 202/4885ALDH1A1 3700/4885
US-20180092938-A1 OLIGONUCLEOTIDE ANALOGUES TARGETING HUMAN LMNA LMNB2, LMNA, LMNB1 USP2 4607/4885POLB 145/4885ALDH1A1 4394/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.