Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 9/20 | 0.43 |
| ▸ | KIT | P10721 | 7/20 | 0.43 |
| ▸ | KDR | P35968 | 5/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.43 |
| ▸ | AURKA | O14965 | 3/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 3/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4082984 | 0.90 | AURKA (0.48) | FLT3KITKDRMCHR1AURKA | |
| SCHEMBL4088412 | 0.88 | ABL1 (0.51) | FLT3KITKDRAURKACLK2 | |
| SCHEMBL4086294 | 0.87 | ABL1 (0.52) | FLT3KITKDRAURKAALK | |
| SCHEMBL4093460 | 0.84 | AURKA (0.48) | FLT3KITKDRAURKAALK | |
| SCHEMBL4089596 | 0.83 | FLT3 (0.49) | FLT3KITKDRMCHR1AURKA | |
| SCHEMBL4084047 | 0.83 | AURKA (0.42) | AURKAHDAC1 | |
| SCHEMBL4088344 | 0.82 | RAB9A (0.46) | FLT3KDRAURKAHDAC1ABL1 | |
| SCHEMBL4082899 | 0.82 | AURKA (0.60) | FLT3KITAURKAALKABL1 | |
| SCHEMBL13850096 | 0.81 | AURKA (0.39) | FLT3AURKAALKCLK2DYRK1A | |
| SCHEMBL4092903 | 0.78 | ABL1 (0.61) | FLT3KITKDRAURKAHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |