Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395257 | 0.72 | MEN1 (0.41) | HPGDKDM4EALDH1A1HSD17B10NPSR1 | |
| SCHEMBL4758299 | 0.71 | LMNA (0.42) | ALDH1A1LMNAMEN1POLBKMT2A | |
| SCHEMBL30678530 | 0.70 | TSHR (0.39) | KDM4EALDH1A1GAAHSD17B10LMNA | |
| SCHEMBL873846 | 0.63 | KEAP1 (0.75) | IKBKBCHUKHPGDKDM4EPTGS2 | |
| SCHEMBL4639252 | 0.63 | NOTUM (0.55) | IKBKBCHUKHPGDKDM4EALDH1A1 | |
| SCHEMBL28201767 | 0.63 | CHUK (0.64) | IKBKBCHUKHPGDKDM4EALDH1A1 | |
| SCHEMBL29788170 | 0.62 | GRIA4 (0.55) | IKBKBCHUKHPGDKDM4EPTGS2 | |
| SCHEMBL2044935 | 0.61 | KIF11 (0.59) | HPGDKDM4EPTGS2ALDH1A1NR3C2 | |
| SCHEMBL28319287 | 0.61 | KEAP1 (0.70) | HPGDKDM4EPTGS2ALDH1A1NR3C2 | |
| SCHEMBL8796720 | 0.61 | ADH5 (0.51) | IKBKBCHUKHPGDKDM4EPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009006580-A1 | OPTIONALLY CONDENSED DIHYDROPYRIDINE, DIHYDROPYRIMIDINE AND DIHYDROPYRANE DERIVATIVES ACTING AS LATE SODIUM CHANNEL BLOCKERS | CV THERAPEUTICS, INC. (US) | 2009-01-08 | — | — | WO | disclosed |