Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.36 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.36 |
| ▸ | CBX7 | O95931 | 1/20 | 0.35 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.35 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | CDC25B | P30305 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4755316 | 0.82 | HCAR2 (0.36) | MEN1KMT2AALDH1A1CNR1 | |
| SCHEMBL4758299 | 0.79 | LMNA (0.42) | MEN1KMT2AALDH1A1TDP1 | |
| SCHEMBL4755372 | 0.78 | TSHR (0.39) | MEN1MAPTKMT2AKDM4EALDH1A1 | |
| SCHEMBL4084609 | 0.74 | PRNP (0.40) | KMT2AKDM4EALDH1A1HPGDTDP1 | |
| SCHEMBL4083951 | 0.72 | IKBKB (0.39) | MEN1MAPTKMT2ANPSR1KDM4E | |
| SCHEMBL3391587 | 0.70 | KDM4E (0.44) | MEN1MAPTKMT2ANPSR1NR4A1 | |
| SCHEMBL3392997 | 0.67 | TDP1 (0.40) | MEN1MAPTKMT2AKDM4EMAPK1 | |
| SCHEMBL4757277 | 0.65 | TSHR (0.34) | NPSR1KDM4EALDH1A1 | |
| SCHEMBL11008245 | 0.61 | LMNA (0.39) | MEN1KMT2ATDP1 | |
| SCHEMBL7464714 | 0.61 | SLC6A3 (0.59) | MEN1MAPTKMT2ANPSR1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229167-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009078934-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-06-25 | — | — | WO | claimed |
| EP-2229167-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009078934-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-06-25 | — | — | WO | disclosed |