Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 15/20 | 0.47 |
| ▸ | GNAI3 | P08754 | 3/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 3/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 3/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL974631 | 0.92 | THRB (0.51) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL18634073 | 0.91 | THRB (0.53) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL9029619 | 0.87 | THRB (0.49) | THRB | |
| Hydrochloric Acid SCHEMBL9029064 | 0.85 | THRB (0.48) | THRBGNAI3GNAO1GNAI1 | |
| SCHEMBL257071 | 0.80 | THRB (0.45) | THRB | |
| Propene SCHEMBL28189504 | 0.79 | GNAO1 (0.53) | GNAI3GNAO1GNAI1 | |
| SCHEMBL5704250 | 0.78 | THRB (0.42) | THRBALOX5 | |
| SCHEMBL13178226 | 0.78 | ALOX5 (0.45) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL8029443 | 0.75 | ALOX5 (0.41) | THRBGNAI3GNAO1GNAI1ALOX5 | |
| SCHEMBL4490796 | 0.75 | SMN1; SMN2 (0.39) | THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517532-B2 | Dihydroxypyridopyrazine-1,6-dione compounds useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2009-04-14 | — | — | US | disclosed |
| US-20060024330-A1 | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors | MERCK SHARP & DOHME CORP. | 2006-02-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060024330-A1 | Dihydroxypyridopyrazine-1,6-dione compounds useful as hiv integrase inhibitors | DHPS, DUT, CDKN1A | THRB 3480/4885GNAI3 2182/4885GNAO1 2521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.