Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 10/20 | 0.44 |
| ▸ | NPC1 | O15118 | 9/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083278 | 0.84 | AURKA (0.42) | PKMMAPTKMT2ANPSR1RAB9A | |
| SCHEMBL4087457 | 0.80 | KLK7 (0.47) | PKMMAPTRAB9ANPC1POLB | |
| SCHEMBL4088557 | 0.80 | SMN1; SMN2 (0.48) | MAPTKMT2ARAB9ANPC1POLB | |
| SCHEMBL4081816 | 0.79 | MAPT (0.47) | PKMMAPTKMT2ARAB9ANPC1 | |
| SCHEMBL4083484 | 0.79 | SMN1; SMN2 (0.51) | PKMMAPTKMT2ARAB9ANPC1 | |
| SCHEMBL4083540 | 0.78 | FGFR1 (0.50) | KMT2ARAB9ANPC1HTTMEN1 | |
| SCHEMBL4089305 | 0.78 | NPC1 (0.42) | MAPTKMT2ANPSR1RAB9ANPC1 | |
| SCHEMBL4078720 | 0.77 | SMN1; SMN2 (0.46) | PKMMAPTKMT2ARAB9ANPC1 | |
| SCHEMBL4088594 | 0.77 | GPR35 (0.55) | KMT2ARAB9ANPC1MEN1 | |
| SCHEMBL4078664 | 0.77 | HPGD (0.44) | RAB9ANPC1HPGDPARP1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |