Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 2/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.34 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081604 | 0.88 | ALDH1A1 (0.46) | CCNE1CDK2GSK3BSMN1; SMN2NPC1 | |
| SCHEMBL4087253 | 0.87 | CASP3 (0.38) | TAS2R8KIFC1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4091948 | 0.84 | NPC1 (0.32) | GSK3BSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL4082223 | 0.84 | KDM4E (0.37) | KIFC1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL4083862 | 0.83 | TAS1R3 (0.38) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL4084026 | 0.83 | MAPT (0.42) | TAS2R8SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL4078418 | 0.83 | HTT (0.43) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL4093454 | 0.83 | JMJD6 (0.38) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL4088615 | 0.82 | KMT2A (0.45) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL4083257 | 0.82 | NAMPT (0.34) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |