Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 7/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | THRB | P10828 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084026 | 0.86 | MAPT (0.42) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4087183 | 0.85 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4078418 | 0.85 | HTT (0.43) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4084062 | 0.84 | ALDH1A1 (0.51) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4084041 | 0.84 | RAB9A (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4088615 | 0.84 | KMT2A (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4093521 | 0.83 | SMN1; SMN2 (0.43) | TAS1R3TAS1R1RAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4091779 | 0.83 | LMNA (0.44) | RAB9ASMN1; SMN2ALDH1A1HPGDKMT2A | |
| SCHEMBL4081200 | 0.83 | MAPT (0.45) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL4087974 | 0.83 | TAS2R8 (0.35) | RAB9ANPC1SMN1; SMN2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |