Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 2/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087974 | 0.87 | TAS2R8 (0.35) | HPGDSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL4081604 | 0.86 | ALDH1A1 (0.46) | HPGDSMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL4078418 | 0.85 | HTT (0.43) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4093454 | 0.85 | JMJD6 (0.38) | HPGDSMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL4083257 | 0.84 | NAMPT (0.34) | HPGDSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL4087183 | 0.84 | RAB9A (0.45) | HPGDSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL4078532 | 0.83 | RAB9A (0.39) | HPGDSMN1; SMN2NPC1RAB9APKM | |
| SCHEMBL4078553 | 0.83 | KDM4E (0.44) | HPGDSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL4083791 | 0.82 | LMNA (0.44) | HPGDSMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL4093521 | 0.82 | SMN1; SMN2 (0.43) | CASP3SENP7HPGDSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |