Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | JMJD6 | Q6NYC1 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | RGS12 | O14924 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.30 |
| ▸ | NMT2 | O60551 | 1/20 | 0.30 |
| ▸ | NMT1 | P30419 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087253 | 0.84 | CASP3 (0.38) | MAOBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4091948 | 0.83 | NPC1 (0.32) | JMJD6MAOBALDH1A1NPC1RAB9A | |
| SCHEMBL4078532 | 0.83 | RAB9A (0.39) | MAOBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4081604 | 0.83 | ALDH1A1 (0.46) | NAMPTALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL4093454 | 0.83 | JMJD6 (0.38) | JMJD6MAOBALDH1A1NPC1RAB9A | |
| SCHEMBL4088615 | 0.83 | KMT2A (0.45) | ALDH1A1NPC1RAB9AMAPTKDM4E | |
| SCHEMBL4087974 | 0.82 | TAS2R8 (0.35) | MAOBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4083862 | 0.81 | TAS1R3 (0.38) | MAOBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4078418 | 0.81 | HTT (0.43) | MAOBALDH1A1NPC1RAB9AMAPT | |
| SCHEMBL4084026 | 0.81 | MAPT (0.42) | ALDH1A1NPC1RAB9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |