Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.37 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.37 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4087974 | 0.88 | TAS2R8 (0.35) | ALDH1A1KDM4EHPGDSMN1; SMN2KMT2A | |
| SCHEMBL4087253 | 0.86 | CASP3 (0.38) | ALDH1A1KDM4EHPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL4078418 | 0.84 | HTT (0.43) | ALDH1A1KDM4EHPGDLMNATSHR | |
| SCHEMBL4078532 | 0.84 | RAB9A (0.39) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4082223 | 0.84 | KDM4E (0.37) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4093454 | 0.84 | JMJD6 (0.38) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4083257 | 0.83 | NAMPT (0.34) | ALDH1A1KDM4EHPGDSMN1; SMN2NPC1 | |
| SCHEMBL4087183 | 0.83 | RAB9A (0.45) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4093521 | 0.83 | SMN1; SMN2 (0.43) | ALDH1A1KDM4EHPGDLMNAHSD17B10 | |
| SCHEMBL4091779 | 0.83 | LMNA (0.44) | ALDH1A1KDM4EHPGDLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |