Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 9/20 | 0.40 |
| ▸ | TP53 | P04637 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078387 | 0.83 | MAPK1 (0.48) | L3MBTL1LMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL4083114 | 0.83 | AURKA (0.41) | ALDH1A1ATML3MBTL1THRBLMNA | |
| SCHEMBL4082112 | 0.81 | KDM4E (0.40) | — | |
| SCHEMBL4083540 | 0.80 | FGFR1 (0.50) | RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL4088564 | 0.79 | MAPT (0.48) | ALDH1A1LMNAMAPTTP53RAB9A | |
| SCHEMBL4092896 | 0.77 | HDAC6 (0.51) | MAPTTP53RAB9AMEN1KMT2A | |
| SCHEMBL4086303 | 0.77 | MAPK1 (0.49) | ALDH1A1ATML3MBTL1MAPTTP53 | |
| SCHEMBL4088652 | 0.77 | JAK2 (0.49) | POLBRAB9AMEN1KMT2ANPC1 | |
| SCHEMBL4088272 | 0.76 | ALDH1A1 (0.40) | ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4078664 | 0.76 | HPGD (0.44) | RAB9AHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |