Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 2/20 | 0.49 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.48 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.42 |
| ▸ | F3 | P13726 | 1/20 | 0.42 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.42 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.42 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.42 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313456 | 0.85 | LOXL2 (0.47) | PLOD2PLOD3PLOD1ALDH1A1LOXL2 | |
| SCHEMBL4091982 | 0.82 | LOXL2 (0.47) | PLOD2PLOD3PLOD1ALDH1A1LOXL2 | |
| SCHEMBL3281996 | 0.81 | ALDH1A1 (0.54) | PLOD2PLOD3PLOD1ALDH1A1IDO1 | |
| SCHEMBL3059074 | 0.80 | PLOD2 (0.59) | PLOD2PLOD3PLOD1ALDH1A1APP | |
| SCHEMBL828092 | 0.79 | RAB9A (0.53) | PLOD2ALDH1A1LOXL2KMT2ALMNA | |
| SCHEMBL2662937 | 0.79 | GAA (0.57) | PLOD2PLOD3PLOD1ALDH1A1APP | |
| SCHEMBL3891876 | 0.79 | VNN1 (0.43) | LOXL2HDAC8CTNNB1WNT3AHDAC6 | |
| SCHEMBL3896447 | 0.79 | ERCC5 (0.46) | ALDH1A1LOXL2KMT2ALMNA | |
| SCHEMBL17672056 | 0.78 | NAPRT (0.65) | PLOD2PLOD3PLOD1ALDH1A1APP | |
| SCHEMBL31326722 | 0.78 | NAPRT (0.65) | PLOD2PLOD3PLOD1ALDH1A1APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | PLOD2 4357/4885PLOD3 4354/4885PLOD1 4324/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | PLOD2 4357/4885PLOD3 4354/4885PLOD1 4324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.