Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.42 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.42 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4313456 | 0.87 | LOXL2 (0.47) | LOXL2PLOD2PLOD3PLOD1CYP3A4 | |
| SCHEMBL828092 | 0.87 | RAB9A (0.53) | LOXL2PLOD2CYP3A4ALDH1A1HPGD | |
| SCHEMBL3618613 | 0.84 | LOXL2 (0.45) | LOXL2CYP3A4ALDH1A1HPGDGABRP | |
| SCHEMBL4090694 | 0.82 | PLOD2 (0.49) | LOXL2PLOD2PLOD3PLOD1ALDH1A1 | |
| SCHEMBL6203734 | 0.80 | ALDH1A1 (0.55) | PLOD2PLOD3PLOD1CYP3A4ALDH1A1 | |
| SCHEMBL5762281 | 0.79 | ALDH1A1 (0.44) | LOXL2CYP3A4ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL3282004 | 0.79 | NAMPT (0.48) | PLOD2PLOD3PLOD1CYP3A4ALDH1A1 | |
| SCHEMBL3891876 | 0.78 | VNN1 (0.43) | LOXL2HPGDFFAR1CTNNB1WNT3A | |
| SCHEMBL3896447 | 0.78 | ERCC5 (0.46) | LOXL2ALDH1A1L3MBTL1KCNQ2LMNA | |
| SCHEMBL13089763 | 0.78 | GABRP (0.62) | LOXL2CYP3A4ALDH1A1HPGDHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION | 2009-08-27 | — | — | US | disclosed |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | INCYTE CORPORATION | 2006-05-18 | — | — | US | disclosed |
| WO-2005105814-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | INCYTE CORPORATION (US) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215766-A1 | TETRACYCLIC INHIBITORS OF JANUS KINASES | JAK1, JAK2, JAK3 | LOXL2 2849/4885PLOD2 4357/4885PLOD3 4354/4885 |
| US-20060106020-A1 | Tetracyclic inhibitors of Janus kinases | JAK1, JAK2, JAK3 | LOXL2 2849/4885PLOD2 4357/4885PLOD3 4354/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.