Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.46 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3880434 | 0.93 | LRRK2 (0.47) | LRRK2CSNK1DMAPTSMN1; SMN2KDM4E | |
| SCHEMBL4083005 | 0.93 | MAPT (0.44) | MAPTSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL4088668 | 0.90 | SMN1; SMN2 (0.54) | MAPTSMN1; SMN2KMT2AMAPK1RAB9A | |
| SCHEMBL4088637 | 0.86 | ALDH1A1 (0.43) | MAPTSMN1; SMN2KDM4EHPGDKMT2A | |
| SCHEMBL4091779 | 0.86 | LMNA (0.44) | MAPTSMN1; SMN2KDM4EHPGDKMT2A | |
| SCHEMBL4078418 | 0.86 | HTT (0.43) | MAPTSMN1; SMN2KDM4EHPGDMEN1 | |
| SCHEMBL3880690 | 0.86 | MAPT (0.46) | MAPTHPGDMEN1KMT2ARAB9A | |
| SCHEMBL4083509 | 0.85 | GPR35 (0.49) | MAPTSMN1; SMN2KDM4EHPGDMEN1 | |
| SCHEMBL4086291 | 0.85 | MAPK1 (0.44) | MAPTSMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL4083518 | 0.85 | LMNA (0.44) | MAPTSMN1; SMN2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | claimed |
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |