Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088619 | 0.90 | GPR35 (0.42) | GPR35ALDH1A1NPC1RAB9AKMT2A | |
| SCHEMBL4083134 | 0.90 | GPR35 (0.42) | GPR35ALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL4088637 | 0.90 | ALDH1A1 (0.43) | GPR35ALDH1A1NPC1NPSR1SMN1; SMN2 | |
| SCHEMBL4091779 | 0.90 | LMNA (0.44) | GPR35ALDH1A1NPSR1RXFP1SMN1; SMN2 | |
| SCHEMBL4078418 | 0.90 | HTT (0.43) | ALDH1A1NPC1SMN1; SMN2RAB9AKMT2A | |
| SCHEMBL4078733 | 0.88 | ALDH1A1 (0.44) | GPR35ALDH1A1RXFP1SMN1; SMN2MAPT | |
| SCHEMBL4082122 | 0.86 | MCHR1 (0.42) | ALDH1A1MAPTKDM4EL3MBTL1 | |
| SCHEMBL4084033 | 0.85 | ELANE (0.45) | GPR35ALDH1A1NPC1LMNAELANE | |
| SCHEMBL4083252 | 0.85 | PTK2 (0.37) | GPR35ALDH1A1NPC1SMN1; SMN2RAB9A | |
| SCHEMBL4083518 | 0.85 | LMNA (0.44) | NPC1SMN1; SMN2RAB9AKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2058315-A1 | 1H-Furo[3,2-C]Pyrazoles active as aurora kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2009-05-13 | — | — | EP | disclosed |