SCHEMBL4097453

SCHEMBL4097453

COC(=O)CCCCCNc1ccnc(-c2ccccn2)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
LMNA P02545 2/20 0.44
HDAC1 Q13547 9/20 0.43
HDAC6 Q9UBN7 9/20 0.43
HDAC3 O15379 2/20 0.43
HDAC4 P56524 2/20 0.43
HDAC7 Q8WUI4 2/20 0.43
HDAC2 Q92769 2/20 0.43
HDAC10 Q969S8 2/20 0.43
HDAC11 Q96DB2 2/20 0.43
HDAC8 Q9BY41 2/20 0.43
HDAC9 Q9UKV0 2/20 0.43
HDAC5 Q9UQL6 2/20 0.43
LTB4R Q15722 1/20 0.43
KDM4E B2RXH2 2/20 0.42
GAA P10253 1/20 0.42
MAPT P10636 1/20 0.42
HSD17B10 Q99714 1/20 0.42
CA1 P00915 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL308214 0.86 KDM4E (0.47) SMN1; SMN2HDAC1HDAC6HDAC3HDAC4
SCHEMBL308968 0.78 HSP90AA1 (0.43) LMNAHDAC1HDAC6HDAC3HDAC4
SCHEMBL29531976 0.78 ALDH1A1 (0.49) ALDH1A1SMN1; SMN2LTB4RKDM4EGAA
SCHEMBL5856769 0.77 ALDH1A1 (0.57) ALDH1A1SMN1; SMN2LMNAHDAC1HDAC6
SCHEMBL1472555 0.76 LMNA (0.66) ALDH1A1SMN1; SMN2LMNAHDAC1HDAC6
Dipyridyl SCHEMBL25299271 0.73 CCR1 (0.42) SMN1; SMN2LMNAKDM4EGAAMAPT
SCHEMBL11115889 0.73 EPHX2 (0.54) ALDH1A1LMNAKDM4EGAAMAPT
SCHEMBL22350388 0.72 LMNA (0.50) ALDH1A1SMN1; SMN2LMNAHDAC1KDM4E
Dipyridyl SCHEMBL5535016 0.72 CCR1 (0.44)
Dipyridyl SCHEMBL5312377 0.72 CCR1 (0.44)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160296147-A1 Redox Polymers THERASENSE, INC. 2016-10-13 US disclosed
US-9320467-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2016-04-26 US disclosed
US-20140364710-A1 Redox Polymers THERASENSE, INC. 2014-12-11 US disclosed
US-8828204-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-09-09 US disclosed
US-8795490-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-08-05 US disclosed
US-8512534-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2013-08-20 US disclosed
US-8444834-B2 Redox polymers for use in analyte monitoring ABBOTT DIABETES CARE INC. (US) 2013-05-21 US disclosed
US-8268143-B2 Oxygen-effect free analyte sensor ABBOTT DIABETES CARE INC. (US) 2012-09-18 US disclosed
US-8268143-B2 Oxygen-effect free analyte sensor ABBOTT DIABETES CARE INC. (US) 2012-09-18 US disclosed
US-20120132525-A1 REDOX POLYMERS FOR USE IN ANALYTE MONITORING ABBOTT DIABETES CARE INC. 2012-05-31 US disclosed
US-20110306111-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2011-12-15 US disclosed
US-20110303537-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2011-12-15 US disclosed
US-20110303538-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2011-12-15 US disclosed
US-7918976-B2 Transition metal complexes with bidentate ligand having an imidazole ring ABBOTT DIABETES CARE INC. (US) 2011-04-05 US disclosed
US-20100288634-A1 Transition Metal Complexes with Bidentate Ligand Having an Imidazole Ring ABBOTT DIABETES CARE INC. 2010-11-18 US disclosed
US-20090145757-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2009-06-11 US disclosed
US-20090145757-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2009-06-11 US disclosed
US-20090099434-A1 OXYGEN-EFFECT FREE ANALYTE SENSOR ABBOTT DIABETES CARE INC. 2009-04-16 US disclosed
US-20090099434-A1 OXYGEN-EFFECT FREE ANALYTE SENSOR ABBOTT DIABETES CARE INC. 2009-04-16 US disclosed
US-20070007132-A1 Transition metal complexes with bidentate ligand having an imidazole ring ABBOTT DIABETES CARE INC. 2007-01-11 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099434-A1 OXYGEN-EFFECT FREE ANALYTE SENSOR LPO, TXN2, PRDX5 ALDH1A1 724/4885SMN1; SMN2 2487/4885LMNA 3343/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.