SCHEMBL308214

SCHEMBL308214

O=C(O)CCCCCNc1ccnc(-c2ccccn2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.47
KDM6B O15054 2/20 0.47
KDM4A O75164 2/20 0.47
KDM5C P41229 2/20 0.47
KDM4C Q9H3R0 2/20 0.47
KDM3A Q9Y4C1 2/20 0.47
KDM2A Q9Y2K7 1/20 0.47
HDAC1 Q13547 10/20 0.46
HDAC6 Q9UBN7 10/20 0.46
HDAC3 O15379 3/20 0.46
HDAC4 P56524 3/20 0.46
HDAC7 Q8WUI4 3/20 0.46
HDAC2 Q92769 3/20 0.46
HDAC10 Q969S8 3/20 0.46
HDAC11 Q96DB2 3/20 0.46
HDAC8 Q9BY41 3/20 0.46
HDAC9 Q9UKV0 3/20 0.46
HDAC5 Q9UQL6 3/20 0.46
ITGB3 P05106 2/20 0.45
ITGAV P06756 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4097453 0.86 ALDH1A1 (0.48) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL308968 0.81 HSP90AA1 (0.43) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL17773820 0.77 MAPT (0.55) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL17773816 0.77 MAPT (0.55) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL17773807 0.77 MAPT (0.55) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL17773812 0.77 MAPT (0.55) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL17773829 0.77 MAPT (0.55) KDM4EKDM6BKDM4AKDM5CKDM4C
SCHEMBL4398060 0.76 ITGB3 (0.68) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL4717622 0.76 ITGB3 (0.68) HDAC1HDAC6HDAC3HDAC4HDAC7
SCHEMBL22691229 0.76 CDC25A (0.43) KDM4EHDAC1HDAC6HDAC3HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10219730-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2019-03-05 US disclosed
US-20160296147-A1 Redox Polymers THERASENSE, INC. 2016-10-13 US disclosed
US-20160296147-A1 Redox Polymers THERASENSE, INC. 2016-10-13 US disclosed
US-9320467-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2016-04-26 US disclosed
US-9320467-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2016-04-26 US disclosed
US-20140364710-A1 Redox Polymers THERASENSE, INC. 2014-12-11 US disclosed
US-20140364710-A1 Redox Polymers THERASENSE, INC. 2014-12-11 US disclosed
US-8828204-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-09-09 US disclosed
US-8828204-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-09-09 US disclosed
US-8795490-B2 Redox polymers ABBOTT DIABETES CARE INC. (US) 2014-08-05 US disclosed
US-20090145757-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2009-06-11 US disclosed
US-20090145757-A1 Redox Polymers ABBOTT DIABETES CARE INC. 2009-06-11 US disclosed
US-20090099434-A1 OXYGEN-EFFECT FREE ANALYTE SENSOR ABBOTT DIABETES CARE INC. 2009-04-16 US disclosed
US-20090099434-A1 OXYGEN-EFFECT FREE ANALYTE SENSOR ABBOTT DIABETES CARE INC. 2009-04-16 US disclosed
US-20070007132-A1 Transition metal complexes with bidentate ligand having an imidazole ring ABBOTT DIABETES CARE INC. 2007-01-11 US disclosed
US-20070007132-A1 Transition metal complexes with bidentate ligand having an imidazole ring ABBOTT DIABETES CARE INC. 2007-01-11 US disclosed
US-7090756-B2 Controller for redox system THERASENSE INC. (US) 2006-08-15 US disclosed
EP-1230249-B1 TRANSITION METAL COMPLEXES WITH BIDENTATE LIGAND HAVING AN IMIDAZOLE RING THERASENSE INC (US) 2004-06-02 EP disclosed
US-20040040840-A1 Controller for redox system THERASENSE, INC. 2004-03-04 US disclosed
US-6605201-B1 Charge transfer compounds comprising osmium compounds coupled to polymers, used as biosensors THERASENSE, INC. 2003-08-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090099434-A1 OXYGEN-EFFECT FREE ANALYTE SENSOR LPO, TXN2, PRDX5 KDM4E 1493/4885KDM6B 1705/4885KDM4A 1454/4885
US-20040040840-A1 Controller for redox system OTC, ME3, PPOX KDM4E 1472/4885KDM6B 2345/4885KDM4A 793/4885
US-10219730-B2 Redox polymers PPOX, OTC, ME3 KDM4E 2030/4885KDM6B 3155/4885KDM4A 1401/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.