Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA5A | P35218 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6944017 | 0.76 | CYP3A4 (0.48) | ALDH1A1GAAMAPTCYP3A4POLB | |
| SCHEMBL1299504 | 0.75 | GAA (0.54) | ALDH1A1GAAKDM4EMAPTCYP3A4 | |
| SCHEMBL29272 | 0.69 | ALDH1A1 (0.46) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL9508013 | 0.67 | ALDH1A1 (0.44) | ALDH1A1KDM4EMAPTMEN1POLB | |
| SCHEMBL1602492 | 0.67 | CALM1 (0.48) | ALDH1A1GAAKDM4EMAPTCYP3A4 | |
| SCHEMBL3918469 | 0.67 | LTA4H (0.48) | ALDH1A1KDM4EMEN1POLBRAB9A | |
| SCHEMBL30561856 | 0.66 | ALDH1A1 (0.44) | ALDH1A1GAAKDM4EMAPTCYP3A4 | |
| SCHEMBL13451834 | 0.66 | SKP2 (0.50) | ALDH1A1GAAKDM4EMAPTCYP3A4 | |
| SCHEMBL1818072 | 0.66 | — | — | |
| SCHEMBL8767382 | 0.66 | HRH3 (0.45) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062550-A1 | Process for the Large Scale Production of Rizatriptan Benzoate | MATRIX LABORATORIES LTD (IN) | 2009-03-05 | — | — | US | disclosed |
| EP-1951713-A1 | PROCESS FOR THE LARGE SCALE PRODUCTION OF RIZATRIPTAN BENZOATE | Matrix Laboratories Ltd (IN) | 2008-08-06 | — | — | EP | disclosed |
| US-7279581-B2 | Process for preparing a pharmaceutically active compound | INKE, S.A. (ES) | 2007-10-09 | — | — | US | disclosed |
| WO-2007054979-A1 | PROCESS FOR THE LARGE SCALE PRODUCTION OF RIZATRIPTAN BENZOATE | MATRIX LABORATORIES LTD (IN) | 2007-05-18 | — | — | WO | disclosed |
| EP-1527053-B1 | PROCESS FOR PREPARING RIZATRIPTAN | VITA CIENTIFICA S L (ES) | 2005-12-07 | — | — | EP | disclosed |
| US-20050148778-A1 | Process for preparing a rizatriptan | INKE, S.A. (ES) | 2005-07-07 | — | — | US | disclosed |
| CN-1157390-C | Indole derivant | — | 2004-07-14 | — | — | CN | disclosed |
| EP-0763032-B1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO INC (US) | 2003-10-15 | — | — | EP | disclosed |
| EP-0925302-B1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO INC (US) | 2002-11-20 | — | — | EP | disclosed |
| CN-1077104-C | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 2002-01-02 | — | — | CN | disclosed |
| CN-1322725-A | Indole derivant | MERCK & CO INC (US) | 2001-11-21 | — | — | CN | disclosed |
| EP-0925302-A1 | PALLADIUM CATALYZED INDOLIZATION | Merck & Co., Inc. (US) | 1999-06-30 | — | — | EP | disclosed |
| US-5811551-A | Palladium catalyzed indolization | MERCK & CO., INC. (US) | 1998-09-22 | — | — | US | disclosed |
| US-5808064-A | HYDROSILATION OF AN INDOLE AS CHEMICAL INTERMEDIATE | MERCK & CO., INC. (US) | 1998-09-15 | — | — | US | disclosed |
| WO-1998006725-A1 | PALLADIUM CATALYZED INDOLIZATION | MERCK & CO., INC. (US) | 1998-02-19 | — | — | WO | disclosed |
| CN-1152920-A | Palladium-Catalyzed Ring Closure of Triazolyl Tryptamine | MERCK & CO INC (US) | 1997-06-25 | — | — | CN | disclosed |
| EP-0763032-A1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO. INC. (US) | 1997-03-19 | — | — | EP | disclosed |
| US-5567824-A | CATALYZING THE CYCLIZATION IN PRESENCE OF A SOLVENT AND A PROTON ACCEPTOR | MERCK & CO., INC. (US) | 1996-10-22 | — | — | US | disclosed |
| WO-1995032197-A1 | PALLADIUM CATALYZED RING CLOSURE OF TRIAZOLYL TRYPTAMINE | MERCK & CO., INC. (US) | 1995-11-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062550-A1 | Process for the Large Scale Production of Rizatriptan Benzoate | DPP4, HTR3A, SI | ALDH1A1 719/4885GAA 673/4885KDM4E 1417/4885 |
| US-20050148778-A1 | Process for preparing a rizatriptan | SI, TPSD1, DPP4 | ALDH1A1 852/4885GAA 1003/4885KDM4E 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.