Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 5/20 | 0.50 |
| ▸ | CASP3 | P42574 | 3/20 | 0.50 |
| ▸ | CASP9 | P55211 | 3/20 | 0.50 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | GNPAT | O15228 | 1/20 | 0.43 |
| ▸ | TASP1 | Q9H6P5 | 1/20 | 0.43 |
| ▸ | ENPEP | Q07075 | 5/20 | 0.42 |
| ▸ | BACE1 | P56817 | 4/20 | 0.41 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.41 |
| ▸ | CASP4 | P49662 | 1/20 | 0.41 |
| ▸ | CASP5 | P51878 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | BMP1 | P13497 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674857 | 1.00 | CASP1 (0.50) | CASP1CASP3CASP9CASP7GNPAT | |
| SCHEMBL13194679 | 1.00 | CASP1 (0.50) | CASP1CASP3CASP9CASP7GNPAT | |
| SCHEMBL29310042 | 1.00 | CASP1 (0.50) | CASP1CASP3CASP9CASP7GNPAT | |
| SCHEMBL10068454 | 0.98 | CASP1 (0.47) | CASP1CASP3CASP9CASP7GNPAT | |
| SCHEMBL29802264 | 0.93 | TASP1 (0.51) | CASP1CASP3CASP9CASP7TASP1 | |
| SCHEMBL20257260 | 0.91 | TASP1 (0.53) | CASP1CASP3CASP9CASP7TASP1 | |
| SCHEMBL20257263 | 0.91 | TASP1 (0.53) | CASP1CASP3CASP9CASP7TASP1 | |
| SCHEMBL29664642 | 0.87 | CASP1 (0.47) | CASP1CASP3CASP9CASP7ENPEP | |
| SCHEMBL23133189 | 0.87 | CASP1 (0.49) | CASP1CASP3CASP9CASP7GNPAT | |
| SCHEMBL23133187 | 0.87 | CASP1 (0.49) | CASP1CASP3CASP9CASP7GNPAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240115649-A1 | CASPASE INHIBITION TO ENHANCE REGENERATION AND REPAIR AFTER SKIN OR GUT INJURY AND TO TREAT BACTERIAL OR VIRAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-04-11 | — | — | US | claimed |
| WO-1996033209-A1 | PEPTIDYL DERIVATIVES AS INHIBITORS OF PRO-APOPTOTIC CYSTEINE PROTEINASES | MERCK FROSST CANADA INC. (CA) | 1996-10-24 | — | — | WO | claimed |
| US-20240115649-A1 | CASPASE INHIBITION TO ENHANCE REGENERATION AND REPAIR AFTER SKIN OR GUT INJURY AND TO TREAT BACTERIAL OR VIRAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2024-04-11 | — | — | US | disclosed |
| US-20230218705-A1 | CASPASE INHIBITORS TO ENHANCE INJURY REPAIR AND TO TREAT BACTERIAL AND VIRAL INFECTIONS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-07-13 | — | — | US | disclosed |
| EP-4126010-A1 | CASPASE INHIBITORS TO ENHANCE INJURY REPAIR AND TO TREAT BACTERIAL AND VIRAL INFECTIONS | The Johns Hopkins University (US) | 2023-02-08 | — | — | EP | disclosed |
| US-20090210956-A1 | COMPOSITION AND METHOD FOR CLUSTERIN-MEDIATED STEM CELL THERAPY FOR TREATMENT OF ATHEROSCLEROSIS AND HEART FAILURE | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-08-20 | — | — | US | disclosed |
| US-7524490-B2 | Clusterin-mediated inhibition of apoptosis via stromal bone marrow cell delivery to a cardiac site | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2009-04-28 | — | — | US | disclosed |
| WO-2006053130-A2 | COMPOSITION AND METHOD FOR CLUSTERIN-MEDIATED STEM CELL THERAPY FOR TREATMENT OF ATHEROSCLEROSIS AND HEART FAILURE | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-05-18 | — | — | WO | disclosed |
| US-20060099194-A1 | Composition and method for clusterin-mediated stem cell therapy for treatment of atherosclerosis and heart failure | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-05-11 | — | — | US | disclosed |
| EP-0822983-A4 | APOPAIN | MERCK & CO INC (US) | 2004-12-15 | — | — | EP | disclosed |
| US-5798442-A | Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases | MERCK FROSST CANADA, INC. (CA) | 1998-08-25 | — | — | US | disclosed |
| EP-0822983-A1 | APOPAIN | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | disclosed |
| WO-1996033209-A1 | PEPTIDYL DERIVATIVES AS INHIBITORS OF PRO-APOPTOTIC CYSTEINE PROTEINASES | MERCK FROSST CANADA INC. (CA) | 1996-10-24 | — | — | WO | disclosed |
| WO-1996033268-A1 | APOPAIN | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |