Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 15/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CCL5 | P13501 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4199259 | 0.86 | CCR5 (0.59) | CCR5CHRM2CHRM1CHRM3 | |
| SCHEMBL411860 | 0.82 | CCR5 (0.50) | CCR5CHRM2KDM4ETP53MDM2 | |
| SCHEMBL4095413 | 0.75 | CCR5 (0.46) | CCR5KDM4E | |
| SCHEMBL27531647 | 0.72 | ALDH1A1 (0.47) | — | |
| SCHEMBL440559 | 0.72 | HSP90AA1 (0.42) | — | |
| Ethylene SCHEMBL8517648 | 0.70 | ALDH1A1 (0.45) | — | |
| SCHEMBL4194662 | 0.70 | CCR5 (0.63) | CCR5CHRM2 | |
| SCHEMBL9425182 | 0.69 | L3MBTL1 (0.49) | KDM4ETP53MDM2TSHR | |
| SCHEMBL7446390 | 0.69 | PKM (0.65) | — | |
| SCHEMBL24120195 | 0.69 | HPGD (0.61) | TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065397-A1 | PREPARATION OF KETONE AMIDES | Scherimg Corporation (US) | 2012-03-15 | — | — | US | disclosed |
| US-20120065397-A1 | PREPARATION OF KETONE AMIDES | Scherimg Corporation (US) | 2012-03-15 | — | — | US | disclosed |
| US-7759487-B2 | Preparation of ketone amides | SCHERING CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| US-7759487-B2 | Preparation of ketone amides | SCHERING CORPORATION (US) | 2010-07-20 | — | — | US | disclosed |
| US-7728135-B2 | Synthesis of CCR5 receptor antagonists | SCHERING CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728135-B2 | Synthesis of CCR5 receptor antagonists | SCHERING CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-20100063280-A1 | PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS | SCHERING CORPORATION | 2010-03-11 | — | — | US | disclosed |
| US-20100063280-A1 | PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS | SCHERING CORPORATION | 2010-03-11 | — | — | US | disclosed |
| US-20100036125-A1 | SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS | SCHERING CORPORATION | 2010-02-11 | — | — | US | disclosed |
| US-20100036125-A1 | SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS | SCHERING CORPORATION | 2010-02-11 | — | — | US | disclosed |
| US-20100029939-A1 | PREPARATION OF KETONE AMIDES | SCHERING CORPORATION | 2010-02-04 | — | — | US | disclosed |
| US-20100029939-A1 | PREPARATION OF KETONE AMIDES | SCHERING CORPORATION | 2010-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100063280-A1 | PROCESS FOR PREPARING CCR-5 RECEPTOR ANTAGONISTS UTILIZING 4-SUBSTITUTED 1-CYCLOPROPANE-SULFONYL-PIPERIDINYL COMPOUNDS | CCR5, CCR4, CCR1 | CCR5 1/4885CHRM2 1106/4885CHRM1 745/4885 |
| US-20100036125-A1 | SYNTHESIS OF CCR5 RECEPTOR ANTAGONISTS | CCR5, CXCR4, CCR2 | CCR5 1/4885CHRM2 1535/4885CHRM1 985/4885 |
| US-20100029939-A1 | PREPARATION OF KETONE AMIDES | CCR5, CCR2, ACKR3 | CCR5 1/4885CHRM2 762/4885CHRM1 707/4885 |
| US-20120065397-A1 | PREPARATION OF KETONE AMIDES | CCR5, CCR2, ACKR3 | CCR5 1/4885CHRM2 762/4885CHRM1 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.