Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.65 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.65 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.65 |
| ▸ | TOP1 | P11387 | 3/20 | 0.64 |
| ▸ | PPARG | P37231 | 5/20 | 0.61 |
| ▸ | PPARD | Q03181 | 4/20 | 0.61 |
| ▸ | PPARA | Q07869 | 4/20 | 0.61 |
| ▸ | TERT | O14746 | 3/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | BLM | P54132 | 3/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.61 |
| ▸ | FABP4 | P15090 | 3/20 | 0.61 |
| ▸ | F7 | P08709 | 2/20 | 0.61 |
| ▸ | F3 | P13726 | 2/20 | 0.61 |
| ▸ | USP2 | O75604 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.61 |
| ▸ | RECQL | P46063 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8984505 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL8984507 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL31382568 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL14224944 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL1946239 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL8984474 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL14270521 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL8984470 | 1.00 | GPR84 (0.65) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL4744794 | 0.98 | GPR84 (0.61) | GPR84FFAR1FFAR4TOP1PPARG | |
| SCHEMBL23225824 | 0.95 | FFAR1 (0.73) | GPR84FFAR1FFAR4TOP1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029131-A2 | METHOD FOR TREATING RENAL DISEASE | M.C.W. Research Foundation, Inc. (US) | 2009-03-04 | — | — | EP | claimed |
| US-20080306155-A1 | METHOD FOR TREATING RENAL DISEASE | ROMAN RICHARD J | 2008-12-11 | — | — | US | claimed |
| WO-2007146262-A2 | METHOD FOR TREATING RENAL DISEASE | MCW RESEARCH FOUNDATION, INC. (US) | 2007-12-21 | — | — | WO | claimed |
| US-20070004802-A1 | Method for treating renal disease | THE MEDICAL COLLEGE OF WISCONSIN, INC. | 2007-01-04 | — | — | US | claimed |
| US-20060063836-A1 | Method for treating renal disease | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2006-03-23 | — | — | US | claimed |
| EP-1056449-B1 | 20-HETE ANTAGONISTS AND AGONISTS | MCW RES FOUND INC (US) | 2003-04-16 | — | — | EP | claimed |
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |
| EP-2029131-A2 | METHOD FOR TREATING RENAL DISEASE | M.C.W. Research Foundation, Inc. (US) | 2009-03-04 | — | — | EP | disclosed |
| US-20080306155-A1 | METHOD FOR TREATING RENAL DISEASE | ROMAN RICHARD J | 2008-12-11 | — | — | US | disclosed |
| US-20080306155-A1 | METHOD FOR TREATING RENAL DISEASE | ROMAN RICHARD J | 2008-12-11 | — | — | US | disclosed |
| US-20080051454-A1 | Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments | THE BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2008-02-28 | — | — | US | disclosed |
| US-20080051454-A1 | Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments | THE BOARD OF TRUSTEES OPERATING MICHIGAN STATE UNIVERSITY (US) | 2008-02-28 | — | — | US | disclosed |
| US-6395781-B1 | REDUCING VASCULAR DIAMETER | MCW RESEARCH FOUNDATION | 2002-05-28 | — | — | US | disclosed |
| US-6395781-B1 | REDUCING VASCULAR DIAMETER | MCW RESEARCH FOUNDATION | 2002-05-28 | — | — | US | disclosed |
| US-20020049244-A1 | 20-HETE antagonists and agonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-04-25 | — | — | US | disclosed |
| US-20020049244-A1 | 20-HETE antagonists and agonists | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-04-25 | — | — | US | disclosed |
| EP-1056449-A2 | 20-HETE ANTAGONISTS AND AGONISTS | MCW Research Foundation, Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043310-A3 | 20-HETE ANTAGONISTS AND AGONISTS | MCW RES FOUND INC (US) | 1999-10-07 | — | — | WO | disclosed |
| WO-1999043310-A2 | 20-HETE ANTAGONISTS AND AGONISTS | MCW RESEARCH FOUNDATION, INC. (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080306155-A1 | METHOD FOR TREATING RENAL DISEASE | ALOX15, ALOX5, ALOX15B | GPR84 1022/4885FFAR1 240/4885FFAR4 433/4885 |
| US-20020049244-A1 | 20-HETE antagonists and agonists | ALOX5, ALOX15, ALOX15B | GPR84 174/4885FFAR1 78/4885FFAR4 47/4885 |
| US-20080051454-A1 | Compositions and methods for transient receptor potential vanilloid (TRPV) channel mediated treatments | TRPV1, TRPV3, TRPV5 | GPR84 165/4885FFAR1 86/4885FFAR4 78/4885 |
| US-20060063836-A1 | Method for treating renal disease | ALOX5, ALOX15, REN | GPR84 869/4885FFAR1 231/4885FFAR4 416/4885 |
| US-20070004802-A1 | Method for treating renal disease | ALOX15, ALOX15B, ALOX5 | GPR84 836/4885FFAR1 42/4885FFAR4 90/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.