Fumaric Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ACE ADRA1A ADRA1B ADRA1D ADRA2A ADRA2B ADRA2C ADRB1 ADRB2 ATP4A ATP4B AXL BTK CACNA1C CACNA1D CACNA1F CACNA1S CCR5 CHRM2 CHRM3 CPT1B CPT2 DPP4 DRD1 DRD2 EGFR ERBB2 ERBB4 FLT3 HRH1 HRH3 HTR1A HTR2A HTR2B HTR2C HTR4 JAK1 JAK2 JAK3 KCNH2 KMT2A MAP2K1 MAP2K2 MEN1 MLNR MPL MTOR P PIK3CA PIK3CB PIK3CD PIK3CG PIK3R1 PIK3R2 PIK3R3 PIK3R5 PLK4 PPARG REN S1PR1 SLC6A2 SLC6A3 SLC6A4 SMO TYK2 atpA atpB atpC atpD atpE atpF atpFH atpG pol

The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	MEN1 known ✓	O00255	4/20	0.34

▸	KMT2A known ✓	Q03164	4/20	0.34

▸	PIK3CD known ✓	O00329	1/20	0.32

▸	PIK3CA known ✓	P42336	1/20	0.32

▸	PIK3CB known ✓	P42338	1/20	0.32

▸	PIK3CG known ✓	P48736	1/20	0.32

▸	NAMPT	P43490	6/20	0.39

▸	MAPT	P10636	2/20	0.34

▸	ALOX15	P16050	2/20	0.34

▸	HTT	P42858	2/20	0.34

▸	PABPC1	P11940	1/20	0.34

▸	USP2	O75604	1/20	0.34

▸	TP53	P04637	1/20	0.34

▸	TSHR	P16473	1/20	0.34

▸	SMN1; SMN2	Q16637	1/20	0.34

▸	NPSR1	Q6W5P4	1/20	0.34

▸	TAS2R14	Q9NYV8	1/20	0.33

▸	ALDH1A1	P00352	1/20	0.33

▸	LMNA	P02545	1/20	0.33

▸	HPGD	P15428	1/20	0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Fumaric Acid SCHEMBL3651799	1.00	NAMPT (0.39)	NAMPTMEN1KMT2AMAPTALOX15
Fumaric Acid SCHEMBL4135452	0.90	NAMPT (0.37)	NAMPTMEN1KMT2AALDH1A1CYP2A6
Fumaric Acid SCHEMBL4135457	0.90	NAMPT (0.37)	NAMPTMEN1KMT2AALDH1A1CYP2A6
Fumaric Acid SCHEMBL4130276	0.87	CYP2A6 (0.34)	NAMPTMEN1KMT2ACYP2A6POLB
Fumaric Acid SCHEMBL4130268	0.87	CYP2A6 (0.34)	NAMPTMEN1KMT2ACYP2A6POLB
Fumaric Acid SCHEMBL4119125	0.85	NFE2L2 (0.35)	MEN1KMT2AMAPTTP53GSK3B
Fumaric Acid SCHEMBL4119118	0.85	NFE2L2 (0.35)	MEN1KMT2AMAPTTP53GSK3B
SCHEMBL4126014	0.83	NAMPT (0.34)	NAMPTMEN1KMT2AMAPTALOX15
Fumaric Acid SCHEMBL3646703	0.82	KDM4E (0.36)	NAMPTMEN1KMT2ATSHRNPSR1
Fumaric Acid SCHEMBL3646707	0.82	KDM4E (0.36)	NAMPTMEN1KMT2ATSHRNPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2190822-B1	5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS	TAKEDA PHARMACEUTICAL (JP)	2014-12-31	—	—	EP	disclosed
US-20090156642-A1	5-Membered heterocyclic compound	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2009-06-18	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20090156642-A1	5-Membered heterocyclic compound	CEL, PGA5, COG5	MEN1 1910/4885KMT2A 4776/4885PIK3CD 1112/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.