Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.59 |
| ▸ | MAOA | P21397 | 5/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CETP | P11597 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL59900 | 0.84 | MAPT (0.62) | CHRNA7MAOAALDH1A1KDM4EGAA | |
| SCHEMBL1274990 | 0.80 | ACHE (0.54) | CHRNA7MAOAPTGS2ALDH1A1KDM4E | |
| SCHEMBL9620643 | 0.80 | ACHE (0.54) | CHRNA7MAOAPTGS2 | |
| SCHEMBL5045112 | 0.79 | MAPT (0.62) | CHRNA7MAOAALDH1A1KDM4EGAA | |
| SCHEMBL29702351 | 0.77 | HTR2A (0.53) | CHRNA7MAOAALDH1A1CYP2D6HSD17B10 | |
| SCHEMBL11099064 | 0.77 | MAOA (0.43) | CHRNA7MAOAPTGS2ALDH1A1CYP2D6 | |
| SCHEMBL32690214 | 0.77 | HTR2A (0.53) | CHRNA7MAOAALDH1A1CYP2D6HSD17B10 | |
| SCHEMBL3505675 | 0.77 | HTR2A (0.53) | CHRNA7MAOAALDH1A1CYP2D6HSD17B10 | |
| SCHEMBL1011463 | 0.77 | HTR2A (0.53) | CHRNA7MAOAALDH1A1CYP2D6HSD17B10 | |
| SCHEMBL8794833 | 0.77 | CHRNA7 (0.49) | CHRNA7MAOAPTGS2ALDH1A1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896391-B1 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | UNIV BAYLOR (US) | 2015-08-12 | — | — | EP | disclosed |
| US-8394859-B2 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY (US) | 2013-03-12 | — | — | US | disclosed |
| US-20090075943-A1 | Combretastatin Analogs with Tubulin Binding Activity | BAYLOR UNIVERSITY | 2009-03-19 | — | — | US | disclosed |
| US-7429681-B2 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY (US) | 2008-09-30 | — | — | US | disclosed |
| EP-1896391-A2 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | Baylor University (US) | 2008-03-12 | — | — | EP | disclosed |
| EP-1263763-B1 | TUBULIN BINDING LIGANDS | UNIV BAYLOR (US) | 2007-07-25 | — | — | EP | disclosed |
| US-20060293394-A1 | Combretastatin analogs with tubulin binding activity | BAYLOR UNIVERSITY | 2006-12-28 | — | — | US | disclosed |
| WO-2006138427-A2 | COMBRETASTATIN ANALOGS WITH TUBULIN BINDING ACTIVITY | BAYLOR UNIVERSITY (US) | 2006-12-28 | — | — | WO | disclosed |
| US-6284789-B1 | TETRAHYDRONAPHTHALENE DERIVATIVES OF ALPHA-CONINDENDRIN, BETA-CONINDENDRIN, SIKKIMOTOXIN, AND PODOPHYLLOTOXIN HAVING AT LEAST ONE METHYLENEOXY BRIDGE WHEREIN THE OXYGEN ATOM EXTENDS TO THE BENZHYDRYLIC CARBON ATOM; ANTICANCER AGENTS | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK | 2001-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293394-A1 | Combretastatin analogs with tubulin binding activity | TUBB, TUBB3, TUBB1 | CHRNA7 4282/4885MAOA 4139/4885PTGS2 3482/4885 |
| US-20090075943-A1 | Combretastatin Analogs with Tubulin Binding Activity | TUBB, TUBB3, TUBB1 | CHRNA7 4282/4885MAOA 4139/4885PTGS2 3482/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.