Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN known ✓ | P00797 | 2/20 | 0.34 |
| ▸ | DRD2 known ✓ | P14416 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 7/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4137848 | 1.00 | CNR1 (0.36) | CNR1NAMPTSLC16A3SLC16A1REN | |
| SCHEMBL3695836 | 0.93 | CNR1 (0.36) | CNR1NAMPTGNRHR | |
| Fumaric Acid SCHEMBL4131542 | 0.90 | SLC16A3 (0.36) | CNR1NAMPTSLC16A3SLC16A1REN | |
| Fumaric Acid SCHEMBL4131538 | 0.90 | SLC16A3 (0.36) | CNR1NAMPTSLC16A3SLC16A1REN | |
| Fumaric Acid SCHEMBL3701692 | 0.90 | NAMPT (0.37) | NAMPT | |
| Fumaric Acid SCHEMBL3701699 | 0.90 | NAMPT (0.37) | NAMPT | |
| Fumaric Acid SCHEMBL3708418 | 0.89 | SLC16A3 (0.32) | CNR1NAMPTSLC16A3SLC16A1 | |
| Fumaric Acid SCHEMBL3708414 | 0.89 | SLC16A3 (0.32) | CNR1NAMPTSLC16A3SLC16A1REN | |
| Fumaric Acid SCHEMBL4131328 | 0.89 | NAMPT (0.35) | CNR1NAMPTSLC16A3SLC16A1ALDH1A1 | |
| Fumaric Acid SCHEMBL4134751 | 0.89 | REN (0.36) | CNR1NAMPTSLC16A3SLC16A1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2190822-B1 | 5-MEMBERED HETEROCYCLIC COMPOUNDS AS PROTON PUMP INHIBITORS | TAKEDA PHARMACEUTICAL (JP) | 2014-12-31 | — | — | EP | disclosed |
| US-20090156642-A1 | 5-Membered heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156642-A1 | 5-Membered heterocyclic compound | CEL, PGA5, COG5 | REN 1158/4885DRD2 4339/4885CNR1 938/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.