Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.38 |
| ▸ | RARB | P10826 | 4/20 | 0.35 |
| ▸ | RARG | P13631 | 4/20 | 0.35 |
| ▸ | RARA | P10276 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414269 | 0.83 | EGFR (0.38) | EPHX2MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL410105 | 0.73 | NOX4 (0.36) | EPHX2ALDH1A1MAPTEGFR | |
| SCHEMBL414270 | 0.73 | CKS1B (0.59) | EPHX2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL411957 | 0.72 | CAMKK2 (0.35) | ALDH1A1MAPTEGFR | |
| SCHEMBL5834424 | 0.69 | RARG (0.56) | RARBRARGRARAMEN1KMT2A | |
| SCHEMBL6368048 | 0.68 | ALDH1A1 (0.46) | EPHX2RARBRARGRARAMEN1 | |
| SCHEMBL411651 | 0.65 | EGFR (0.43) | MEN1KMT2AALDH1A1MAPTALOX15 | |
| SCHEMBL6878528 | 0.65 | KMT2A (0.51) | EPHX2RARBRARGRARAMEN1 | |
| SCHEMBL18040211 | 0.65 | RARB (0.45) | EPHX2RARBRARGRARAMEN1 | |
| SCHEMBL5475249 | 0.64 | KDM4E (0.53) | EPHX2RARBRARGRARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |