Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | KDM5A | P29375 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 5/20 | 0.34 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | SKP1 | P63208 | 1/20 | 0.33 |
| ▸ | RGS12 | O14924 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL414360 | 0.83 | EPHX2 (0.38) | EGFREPHX2KDM5AKDM5BALDH1A1 | |
| SCHEMBL415184 | 0.78 | EGFR (0.62) | EGFRCKS1BSKP2HSP90AA1SKP1 | |
| SCHEMBL414270 | 0.74 | CKS1B (0.59) | EGFREPHX2CKS1BSKP2P2RX7 | |
| SCHEMBL412797 | 0.74 | ALDH1A1 (0.38) | EGFRRGS12ALDH1A1LCKMAPT | |
| SCHEMBL410105 | 0.72 | NOX4 (0.36) | EGFREPHX2RGS12ALDH1A1LCK | |
| SCHEMBL411957 | 0.71 | CAMKK2 (0.35) | EGFRRGS12ALDH1A1LCKMAPT | |
| SCHEMBL8740875 | 0.67 | P2RX7 (0.49) | KDM5AKDM5BP2RX7MEN1KMT2A | |
| SCHEMBL27759391 | 0.67 | RARB (0.46) | EPHX2KDM5AKDM5BP2RX7ALDH1A1 | |
| SCHEMBL411651 | 0.64 | EGFR (0.43) | EGFRALDH1A1MAPTNOX4MEN1 | |
| SCHEMBL411652 | 0.62 | KDM4C (0.34) | FABP4ALDH1A1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120021519-A1 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) | 2012-01-26 | — | — | US | disclosed |
| WO-2010033906-A2 | EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2010-03-25 | — | — | WO | disclosed |