SCHEMBL4148749

SCHEMBL4148749

CCNC(=O)c1ccccc1Cl

nearest known ligand 0.70

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
HPGD P15428 6/20 0.70
ALDH1A1 P00352 2/20 0.69
POLB P06746 2/20 0.62
CYP1A2 P05177 2/20 0.62
NPC1 O15118 4/20 0.60
RAB9A P51151 4/20 0.60
SMN1; SMN2 Q16637 1/20 0.55
GPR139 Q6DWJ6 1/20 0.55
CYP2C19 P33261 1/20 0.55
MAPT P10636 1/20 0.53
L3MBTL1 Q9Y468 1/20 0.53
P2RX7 Q99572 1/20 0.53

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483721 0.86 HTT (0.64) HPGDALDH1A1L3MBTL1
SCHEMBL26417076 0.86 HTT (0.64) HPGDALDH1A1L3MBTL1
SCHEMBL28763778 0.85 HPGD (0.53) HPGDALDH1A1CYP1A2NPC1RAB9A
SCHEMBL4158170 0.85 TAS1R3 (0.64) HPGDALDH1A1GPR139P2RX7
SCHEMBL10792384 0.85 HPGD (0.81) HPGDALDH1A1POLBCYP1A2NPC1
SCHEMBL10605231 0.82 POLB (0.64) HPGDALDH1A1POLBCYP1A2NPC1
SCHEMBL6358749 0.82 HPGD (1.00) HPGDALDH1A1POLBCYP1A2NPC1
SCHEMBL13754086 0.82 HPGD (0.51) HPGDALDH1A1POLBCYP1A2NPC1
SCHEMBL28214367 0.81 HPGD (0.61) HPGDALDH1A1POLBCYP1A2NPC1
SCHEMBL19302643 0.81 HPGD (0.61) HPGDALDH1A1POLBCYP1A2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0751123-B1 Method for producing alkylsulfinylbenzamides SUMITOMO SEIKA CHEMICALS (JP) 2000-05-10 EP claimed
US-5672751-A TREATMENT OF A HALOBENZAMIDE WITH AN ALKANETHIOL IN THE PRESENCE OF A PHASE TRANSFER CATALYST SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-09-30 US claimed
EP-0751123-A2 Method for producing alkylsulfinylbenzamides SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-01-02 EP claimed
EP-0657438-A2 Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1995-06-14 EP claimed
US-12351580-B2 NLRP3 modulators INNATE TUMOR IMMUNITY, INC. (US) 2025-07-08 US disclosed
US-20240067649-A1 NLRP3 MODULATORS INNATE TUMOR IMMUNITY INC (US) 2024-02-29 US disclosed
US-11827632-B2 NLRP3 modulators INNATE TUMOR IMMUNITY, INC (US) 2023-11-28 US disclosed
US-20220289736-A1 NLRP3 MODULATORS INNATE TUMOR IMMUNITY INC (US) 2022-09-15 US disclosed
US-20210371416-A1 NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES RHIZEN PHARMACEUTICALS AG (CH) 2021-12-02 US disclosed
US-20210161869-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2021-06-03 US disclosed
US-20200157096-A1 NLRP3 MODULATORS INNATE TUMOR IMMUNITY INC (US) 2020-05-21 US disclosed
US-20190055236-A1 NLRP3 MODULATORS INNATE TUMOR IMMUNITY, INC. 2019-02-21 US disclosed
US-5672751-A TREATMENT OF A HALOBENZAMIDE WITH AN ALKANETHIOL IN THE PRESENCE OF A PHASE TRANSFER CATALYST SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-09-30 US disclosed
EP-0751123-A2 Method for producing alkylsulfinylbenzamides SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1997-01-02 EP disclosed
US-5508416-A HALOGENATING A 2-(ALKYLTHIO)BENZAMIDE, CYCLIZATION TO HETERO RING AND N-S LINKAGE SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1996-04-16 US disclosed
US-5498630-A SUBSTITUTED BENZOTHIOPHENECARBOXAMIDES MONSANTO COMPANY (US) 1996-03-12 US disclosed
EP-0657438-A2 Method for producing alkylsulfinylbenzamides and 1,2-benzisothiazol-3-ones SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) 1995-06-14 EP disclosed
CN-1085221-A Bactericide for preventing and treating plant take-all disease MONSANTO CO (US) 1994-04-13 CN disclosed
WO-1993007751-A1 FUNGICIDES FOR THE CONTROL OF TAKE-ALL DISEASE OF PLANTS MONSANTO COMPANY (US) 1993-04-29 WO disclosed
EP-0538231-A1 Fungicides for the control of take-all disease of plants MONSANTO COMPANY (US) 1993-04-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827632-B2 NLRP3 modulators NLRP3, NLRP1, NOD1 HPGD 1183/4885ALDH1A1 3584/4885POLB 4309/4885
US-20220289736-A1 NLRP3 MODULATORS NLRP3, NLRP1, NOD1 HPGD 1183/4885ALDH1A1 3584/4885POLB 4309/4885
US-12351580-B2 NLRP3 modulators NLRP3, NLRP1, NOD1 HPGD 1183/4885ALDH1A1 3584/4885POLB 4309/4885
US-20190055236-A1 NLRP3 MODULATORS NLRP3, NLRP1, NOD1 HPGD 1183/4885ALDH1A1 3584/4885POLB 4309/4885
US-20200157096-A1 NLRP3 MODULATORS NLRP3, NLRP1, NOD1 HPGD 1183/4885ALDH1A1 3584/4885POLB 4309/4885
US-20240067649-A1 NLRP3 MODULATORS NLRP3, NLRP1, NOD1 HPGD 1183/4885ALDH1A1 3584/4885POLB 4309/4885
US-20210161869-A1 ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS DGAT2, MGAT2, MGAT1 HPGD 951/4885ALDH1A1 284/4885POLB 3400/4885
US-20210371416-A1 NOVEL 3,5-DISUBSTITUTED-3H-IMIDAZO[4,5-B]PYRIDINE AND 3,5- DISUBSTITUTED -3H-[1,2,3]TRIAZOLO[4,5-B] PYRIDINE COMPOUNDS AS MODULATORS OF C-MET PROTEIN KINASES MET, PRKCH, PRKCE HPGD 3950/4885ALDH1A1 3113/4885POLB 4262/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.