Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8300378 | 0.81 | LMNA (0.34) | LMNAHSP90AA1 | |
| SCHEMBL8300208 | 0.78 | LMNA (0.39) | L3MBTL1LMNARAB9ANPC1TDP1 | |
| SCHEMBL8300210 | 0.78 | LMNA (0.39) | L3MBTL1LMNARAB9ANPC1TDP1 | |
| SCHEMBL8304062 | 0.76 | LMNA (0.40) | L3MBTL1SMN1; SMN2LMNARAB9ANPC1 | |
| SCHEMBL7211340 | 0.73 | LMNA (0.45) | SMN1; SMN2LMNAHSP90AA1TSHR | |
| SCHEMBL11611749 | 0.72 | — | — | |
| SCHEMBL8470578 | 0.72 | — | — | |
| SCHEMBL31061865 | 0.72 | — | — | |
| SCHEMBL2874801 | 0.72 | NPC1 (0.61) | L3MBTL1SMN1; SMN2PKMLMNARAB9A | |
| SCHEMBL3647399 | 0.72 | NPC1 (0.61) | L3MBTL1SMN1; SMN2PKMLMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0674628-B1 | CHEMOPREVENTIVE COMPOUNDS AND A PREPARATION METHOD AND USE THEREOF | KIM NAK DOO (KR) | 1999-12-22 | — | — | EP | claimed |
| US-5658913-A | THIOPYRAZINE DERIVATIVES; ENZYME INHIBITOR OF PHASE 1 REACTION TO PREVENT THE FORMATION OF ACTIVATED TOXIC INTERMEDIATE METABOLITES AND INDUCE PHASE LL CONJUGATION REACTIONS TO PROMOTE EXCRETION OF TOXICS | Kim, Nak Doo (KR) | 1997-08-19 | — | — | US | claimed |
| EP-0674628-A1 | NEW CHEMOPREVENTIVE COMPOUNDS AND A PREPARATION METHOD AND USE THEREOF | Kim, Nak Doo (KR) | 1995-10-04 | — | — | EP | claimed |
| WO-1995011236-A1 | NEW CHEMOPREVENTIVE COMPOUNDS AND A PREPARATION METHOD AND USE THEREOF | CHUNG, WON, KEUN (KR) | 1995-04-27 | — | — | WO | claimed |
| US-20090181973-A1 | Medicinal composition comprising 3-alkoxy-6-allylthiopyridazines for prevention or treatment of cancer of the pancreas | SEOUL PHARM. CO., LTD. (KR) | 2009-07-16 | — | — | US | disclosed |
| WO-2007058394-A1 | MEDICINAL COMPOSITION COMPRISING 3-ALKOXY-6-ALLYLTHIOPYRIDAZINES FOR PREVENTION OR TREATMENT OF CANCER OF THE PANCREAS | SEOUL PHARM. CO., LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |
| US-20030114379-A1 | Methods of treating or preventing cell, tissue, and organ damage using human myeloid progenitor inhibitory factor-1 (MPIF-1) | HUMAN GENOME SCIENCES, INC. | 2003-06-19 | — | — | US | disclosed |
| US-6495129-B1 | Methods of inhibiting hematopoietic stem cells using human myeloid progenitor inhibitory factor-1 (MPIF-1) (Ckbeta-8/MIP-3) | HUMAN GENOME SCIENCES, INC. | 2002-12-17 | — | — | US | disclosed |
| EP-1225911-A1 | METHODS OF TREATING OR PREVENTING CELL, TISSUE, AND ORGAN DAMAGE USING HUMAN MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) | Human Genome Sciences (US) | 2002-07-31 | — | — | EP | disclosed |
| WO-2001026676-A1 | METHODS OF TREATING OR PREVENTING CELL, TISSUE, AND ORGAN DAMAGE USING HUMAN MYELOID PROGENITOR INHIBITORY FACTOR-1 (MPIF-1) | HUMAN GENOME SCIENCES, INC. (US) | 2001-04-19 | — | — | WO | disclosed |
| EP-0674628-B1 | CHEMOPREVENTIVE COMPOUNDS AND A PREPARATION METHOD AND USE THEREOF | KIM NAK DOO (KR) | 1999-12-22 | — | — | EP | disclosed |
| CN-1043887-C | Chemically resistant compounds, their preparation and use | KIM NAK DOO (KR) | 1999-06-30 | — | — | CN | disclosed |
| US-5658913-A | THIOPYRAZINE DERIVATIVES; ENZYME INHIBITOR OF PHASE 1 REACTION TO PREVENT THE FORMATION OF ACTIVATED TOXIC INTERMEDIATE METABOLITES AND INDUCE PHASE LL CONJUGATION REACTIONS TO PROMOTE EXCRETION OF TOXICS | Kim, Nak Doo (KR) | 1997-08-19 | — | — | US | disclosed |
| CN-1115981-A | New chemopreventive compounds and a preparation method and use thereof | WON KEUN CHUNG (KR) | 1996-01-31 | — | — | CN | disclosed |
| EP-0674628-A1 | NEW CHEMOPREVENTIVE COMPOUNDS AND A PREPARATION METHOD AND USE THEREOF | Kim, Nak Doo (KR) | 1995-10-04 | — | — | EP | disclosed |
| WO-1995011236-A1 | NEW CHEMOPREVENTIVE COMPOUNDS AND A PREPARATION METHOD AND USE THEREOF | CHUNG, WON, KEUN (KR) | 1995-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181973-A1 | Medicinal composition comprising 3-alkoxy-6-allylthiopyridazines for prevention or treatment of cancer of the pancreas | PNLIP, CASP3, AMY2A | L3MBTL1 2499/4885SMN1; SMN2 1207/4885PKM 1887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.