SCHEMBL4157626

SCHEMBL4157626

CC(C)C(=O)N(C)C(C)C

nearest known ligand 0.37

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.31
DPP4 P27487 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25896156 0.89
SCHEMBL27414962 0.84 DPP4 (0.31) DPP4
SCHEMBL31093201 0.79 TP53 (0.40)
SCHEMBL8229447 0.79 TP53 (0.40)
SCHEMBL22648937 0.78
SCHEMBL25280520 0.77 ALDH1A1 (0.38)
SCHEMBL14308894 0.77 DPP4 (0.32) DPP4
SCHEMBL18909888 0.77 DPP4 (0.32) DPP4
SCHEMBL22648833 0.77 DPP4 (0.32) DPP4
SCHEMBL19882798 0.77 DPP4 (0.36) DPP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 261 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110950884-B Di-ring derivative-containing inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-03-26 CN disclosed
US-20240067642-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2024-02-29 US disclosed
US-20240067642-A1 COMPOUNDS AND USES THEREOF FOGHORN THERAPEUTICS INC. 2024-02-29 US disclosed
US-20240024497-A1 METHODS FOR THE SYNTHESIS OF PROTEIN-DRUG CONJUGATES CIDARA THERAPEUTICS, INC. 2024-01-25 US disclosed
US-11857519-B2 Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide ARVINAS OPERATIONS, INC. (US) 2024-01-02 US disclosed
US-20230382915-A1 GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF DECIPHERA PHARMACEUTICALS, LLC 2023-11-30 US disclosed
US-20230374035-A1 RAS INHIBITORS Revolution Medicines, Inc. 2023-11-23 US disclosed
US-20230372496-A1 TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS C4 THERAPEUTICS, INC. (US) 2023-11-23 US disclosed
US-20230372528-A1 GLYCOCONJUGATES UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. 2023-11-23 US disclosed
US-11820751-B2 Urolithin derivatives and methods of use thereof VANDRIA SA (CH) 2023-11-21 US disclosed
US-7446129-B2 Benzylated PDE4 inhibitors BIOLIPOX AB (DE) 2008-11-04 US disclosed
US-20080019978-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF SCHERING CORPORATION 2008-01-24 US disclosed
US-20080015179-A1 Modulators of muscarinic receptors VERTEX PHARMACEUTICALS INCORPORATED 2008-01-17 US disclosed
US-20070208181-A1 BENZYLATED PDE4 INHIBITORS INFLAZYME PHARMACEUTICALS LTD. (CA) 2007-09-06 US disclosed
US-20070208181-A1 BENZYLATED PDE4 INHIBITORS INFLAZYME PHARMACEUTICALS LTD. (CA) 2007-09-06 US disclosed
US-20070066630-A1 Nitrogen-containing heterocyclic compounds and methods of use thereof MERCK SHARP & DOHME LLC 2007-03-22 US disclosed
US-20070032493-A1 Method for treating B cell regulated autoimmune disorders SYNTA PHARMACEUTICALS CORP. (US) 2007-02-08 US disclosed
US-20070032478-A1 Kinase Inhibitors ALLERGAN, INC. 2007-02-08 US disclosed
CN-1863456-A Surfactant/solvent mixtures BAYER CROPSCIENCE GMBH (DE) 2006-11-15 CN disclosed
US-20050064004-A1 Surfactant/solvent mixtures BAYER CROPSCIENCE GMBH (DE) 2005-03-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (15 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230372496-A1 TRICYCLIC HETEROBIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF TARGETED PROTEINS CRBN, CDR2, MDM2 MLYCD 1911/4885DPP4 4214/4885
US-20240024497-A1 METHODS FOR THE SYNTHESIS OF PROTEIN-DRUG CONJUGATES RNGTT, RNMT, DNPEP MLYCD 2402/4885DPP4 372/4885
US-20230372528-A1 GLYCOCONJUGATES CD22, SIGLEC7, CD47 MLYCD 1070/4885DPP4 531/4885
US-20080019978-A1 NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF CYP11B2, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CYP11B1 MLYCD 1191/4885DPP4 2851/4885
US-20070066630-A1 Nitrogen-containing heterocyclic compounds and methods of use thereof CYP11B2, CYP11B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 MLYCD 1236/4885DPP4 2861/4885
US-20230382915-A1 GCN2 AND PERK KINASE INHIBITORS AND METHODS OF USE THEREOF EIF2AK4, GCN1, EEF2K MLYCD 2813/4885DPP4 2654/4885
US-20080015179-A1 Modulators of muscarinic receptors CHRM3, CHRM5, CHRM2 MLYCD 2445/4885DPP4 1478/4885
US-11857519-B2 Compounds and methods for the targeted degradation of enhancer of zeste homolog 2 polypeptide CRBN, MDM2, VHL MLYCD 1702/4885DPP4 3756/4885
US-20070208181-A1 BENZYLATED PDE4 INHIBITORS PDE4B, PDE4A, PDE3B MLYCD 2214/4885DPP4 20/4885
US-20230374035-A1 RAS INHIBITORS KRAS, NRAS, HRAS MLYCD 2598/4885DPP4 2889/4885
US-20070032493-A1 Method for treating B cell regulated autoimmune disorders REL, NFATC1, BCL6 MLYCD 2033/4885DPP4 3069/4885
US-20050064004-A1 Surfactant/solvent mixtures C1R, C1S, HRH4 MLYCD 3807/4885DPP4 4849/4885
US-11820751-B2 Urolithin derivatives and methods of use thereof NLN, UQCRC2, TUFM MLYCD 162/4885DPP4 1868/4885
US-20240067642-A1 COMPOUNDS AND USES THEREOF VHL, TFEB, BECN1 MLYCD 1195/4885DPP4 3672/4885
US-20070032478-A1 Kinase Inhibitors ABL1, LCK, ERBB2 MLYCD 1345/4885DPP4 3519/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.