Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 7/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.42 |
| ▸ | MGLL | Q99685 | 3/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.38 |
| ▸ | KHK | P50053 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1814722 | 0.87 | KHK (0.44) | SMOCYP11B2CYP11B1MGLLNR3C1 | |
| SCHEMBL4169878 | 0.84 | MGLL (0.42) | MGLLHPGDS | |
| SCHEMBL4012517 | 0.80 | GCG (0.35) | — | |
| SCHEMBL4790266 | 0.77 | CDK9 (0.42) | — | |
| SCHEMBL3846301 | 0.76 | SCN9A (0.41) | — | |
| SCHEMBL3862104 | 0.76 | SCN9A (0.41) | — | |
| SCHEMBL3846304 | 0.73 | HTR2C (0.42) | — | |
| SCHEMBL4162409 | 0.73 | FFAR4 (0.33) | — | |
| SCHEMBL4164731 | 0.73 | FFAR4 (0.33) | — | |
| SCHEMBL4167473 | 0.73 | MGLL (0.35) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | claimed |
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | disclosed |