Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 8/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.40 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4793189 | 0.91 | HRH3 (0.40) | CDK9HRH3PRPS1IDO1FLT3 | |
| SCHEMBL4792689 | 0.85 | CDK9 (0.44) | CDK9HRH3PRPS1IDO1FLT3 | |
| SCHEMBL4792357 | 0.83 | PRPS1 (0.40) | CDK9PRPS1 | |
| SCHEMBL4791769 | 0.83 | HRH3 (0.38) | CDK9HRH3IDO1 | |
| SCHEMBL4792148 | 0.79 | CDK9 (0.42) | CDK9HRH3PRPS1FLT3 | |
| SCHEMBL4158337 | 0.77 | SMO (0.44) | — | |
| SCHEMBL2884746 | 0.75 | HRH3 (0.51) | HRH3 | |
| SCHEMBL4012517 | 0.75 | GCG (0.35) | HRH3 | |
| SCHEMBL4169878 | 0.74 | MGLL (0.42) | — | |
| SCHEMBL4790952 | 0.74 | HRH3 (0.42) | HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | claimed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | claimed |
| EP-1994022-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2008-11-26 | — | — | EP | disclosed |
| WO-2007108936-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2007-09-27 | — | — | WO | disclosed |