Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCG | P01275 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 9/20 | 0.34 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.34 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.33 |
| ▸ | PARP3 | Q9Y6F1 | 3/20 | 0.33 |
| ▸ | TNKS | O95271 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.33 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.33 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.33 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.33 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158337 | 0.80 | SMO (0.44) | — | |
| SCHEMBL4169878 | 0.80 | MGLL (0.42) | KCNH2MAPTMEN1RECQLKMT2A | |
| SCHEMBL3846301 | 0.76 | SCN9A (0.41) | KDM2BPARP10HRH3 | |
| SCHEMBL3862104 | 0.76 | SCN9A (0.41) | KDM2BPARP10HRH3 | |
| SCHEMBL4790266 | 0.75 | CDK9 (0.42) | HRH3 | |
| SCHEMBL3846304 | 0.73 | HTR2C (0.42) | KDM2BSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL3843546 | 0.72 | HTR2C (0.41) | KDM2BSLC6A2SLC6A4SLC6A3KCNH2 | |
| SCHEMBL4161023 | 0.71 | HRH3 (0.52) | KCNH2HRH3 | |
| SCHEMBL4162409 | 0.71 | FFAR4 (0.33) | PARP1SLC6A2SLC6A4SLC6A3MAPT | |
| SCHEMBL4164731 | 0.71 | FFAR4 (0.33) | PARP1SLC6A2SLC6A4SLC6A3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074088-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | Wyeth (US) | 2009-07-01 | — | — | EP | claimed |
| WO-2008045371-A2 | N-SUBSTITUTED-AZACYCLYLAMINES AS HISTAMINE-3 ANTAGONISTS | WYETH (US) | 2008-04-17 | — | — | WO | claimed |