Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | KLK7 | P49862 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA3 | P07451 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.52 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4158526 | 1.00 | PKM (0.62) | PKMKLK7KMT2AALDH1A1USP2 | |
| SCHEMBL4162007 | 1.00 | PKM (0.62) | PKMKLK7KMT2AALDH1A1USP2 | |
| SCHEMBL18134893 | 0.92 | PKM (0.67) | PKMKLK7KMT2AALDH1A1USP2 | |
| SCHEMBL10692649 | 0.92 | PKM (0.76) | PKMKLK7KMT2AALDH1A1USP2 | |
| SCHEMBL9502645 | 0.90 | PKM (0.59) | PKMKLK7KMT2AALDH1A1USP2 | |
| SCHEMBL10689090 | 0.90 | ALDH1A1 (0.69) | PKMKLK7KMT2AALDH1A1USP2 | |
| SCHEMBL10693524 | 0.89 | KMT2A (0.70) | PKMKLK7KMT2AALDH1A1TSHR | |
| SCHEMBL10692448 | 0.85 | POLB (0.59) | KMT2AALDH1A1TSHRCYP3A4GLS | |
| SCHEMBL10694568 | 0.84 | ALDH1A1 (0.57) | PKMKMT2AALDH1A1USP2TSHR | |
| SCHEMBL9503442 | 0.84 | CYP2D6 (0.66) | PKMKLK7KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311318-A1 | SUBSTITUTED (S)-BENZOXAZINONES | P&H THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090311318-A1 | SUBSTITUTED (S)-BENZOXAZINONES | P&H THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| US-20090311318-A1 | SUBSTITUTED (S)-BENZOXAZINONES | P&H THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | US | disclosed |
| WO-2009108722-A2 | SUBSTITUTED BENZOXAZINONES | P & H THERAPEUTICS, INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| WO-2009108722-A2 | SUBSTITUTED BENZOXAZINONES | P & H THERAPEUTICS, INC. (US) | 2009-09-03 | — | — | WO | disclosed |
| US-20090215763-A1 | SUBSTITUTED BENZOXAZINONES | P&H THERAPEUTICS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
| US-20090215763-A1 | SUBSTITUTED BENZOXAZINONES | P&H THERAPEUTICS, INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215763-A1 | SUBSTITUTED BENZOXAZINONES | REN, ACE, AGTR1 | PKM 2543/4885KLK7 638/4885KMT2A 4031/4885 |
| US-20090311318-A1 | SUBSTITUTED (S)-BENZOXAZINONES | REN, ACE, AGTR1 | PKM 1385/4885KLK7 476/4885KMT2A 4044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.