Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1H | O95180 | 6/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL4157382 | 0.88 | ALDH1A1 (0.58) | CYP2D6ALDH1A1CYP2C19CYP1A2USP2 | |
| Iodide SCHEMBL4152051 | 0.86 | MAPT (0.48) | ALDH1A1USP2TSHR | |
| Iodide SCHEMBL4156720 | 0.85 | MAPT (0.57) | ALDH1A1KMT2ATSHRSMN1; SMN2 | |
| Iodide SCHEMBL4155309 | 0.84 | CACNA1H (0.47) | CACNA1HCYP2D6ALDH1A1CYP2C19CYP1A2 | |
| SCHEMBL5239194 | 0.83 | MAPT (0.58) | ALDH1A1KMT2ATSHRSMN1; SMN2 | |
| Iodide SCHEMBL4154016 | 0.82 | CACNA1H (0.41) | CACNA1HCYP2D6ALDH1A1CYP2C19CYP1A2 | |
| Bromide SCHEMBL4171632 | 0.82 | MAPT (0.57) | ALDH1A1KMT2ATSHRSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL4162672 | 0.82 | MAPT (0.57) | ALDH1A1KMT2ATSHRSMN1; SMN2 | |
| Iodide SCHEMBL4155323 | 0.81 | NPSR1 (0.59) | ALDH1A1KMT2A | |
| Iodide SCHEMBL4159179 | 0.78 | LMNA (0.51) | ALDH1A1CYP2C19CYP1A2KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090118303-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2009-05-07 | — | — | US | disclosed |
| US-7485646-B2 | Serotonin 5-HT3 receptor agonist | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2009-02-03 | — | — | US | disclosed |
| US-20070265277-A1 | Serotonin 5-Ht3 Receptor Agonist | RESEARCH FOUNDATION ITSUU LABORATORY (JP) | 2007-11-15 | — | — | US | disclosed |
| EP-1798227-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | Research Foundation Itsuu Laboratory (JP) | 2007-06-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090118303-A1 | SEROTONIN 5-HT3 RECEPTOR AGONIST | HTR3A, HTR7, HTR1A | CACNA1H 794/4885CYP2D6 1577/4885ALDH1A1 2805/4885 |
| US-20070265277-A1 | Serotonin 5-Ht3 Receptor Agonist | HTR3A, HTR7, HTR1A | CACNA1H 794/4885CYP2D6 1577/4885ALDH1A1 2805/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.