SCHEMBL2137605

SCHEMBL2137605

Cc1cc(C#N)cc(C(=O)NC(C)C)c1NC(=O)c1cc(Br)nn1-c1ccccc1Cl

nearest known ligand 0.51

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.35
CNR1 P21554 6/20 0.35
CNR2 P34972 3/20 0.35
GCK P35557 1/20 0.34
KCNH2 Q12809 1/20 0.34
KMT2A Q03164 2/20 0.34
MEN1 O00255 1/20 0.34
CETP P11597 1/20 0.34
PDE4A P27815 1/20 0.33
PDE4B Q07343 1/20 0.33
PDE4C Q08493 1/20 0.33
PDE4D Q08499 1/20 0.33
RIPK1 Q13546 2/20 0.33
DHODH Q02127 1/20 0.33
EGLN1 Q9GZT9 1/20 0.33
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2138320 0.91 MEN1 (0.35) TP53CNR1KMT2AMEN1CETP
SCHEMBL30078383 0.88 DHODH (0.41) GCKKCNH2KMT2APDE4APDE4B
SCHEMBL563173 0.88 DHODH (0.41) GCKKCNH2KMT2APDE4APDE4B
SCHEMBL1385164 0.86 PYGL (0.38) TP53CNR1CNR2KMT2ARIPK1
SCHEMBL4165682 0.85 CNR1 (0.38) TP53CNR1CNR2KMT2AMEN1
SCHEMBL10140235 0.83 PDE4A (0.36) KCNH2KMT2APDE4APDE4BPDE4C
SCHEMBL4664524 0.83 TSHR (0.38) TP53CNR1CNR2KMT2ARIPK1
SCHEMBL12052429 0.82 GCK (0.33) TP53CNR1CNR2GCKKCNH2
SCHEMBL5620274 0.81 DHODH (0.39) GCKKCNH2KMT2APDE4APDE4B
SCHEMBL11893257 0.81 PDE4A (0.36) KCNH2KMT2AMEN1PDE4APDE4B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US claimed
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2018-06-21 US disclosed
US-9826737-B2 Solid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2017-11-28 US disclosed
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE E I DUPONT DE NEMOURS AND COMPANY 2017-08-03 US disclosed
US-9332756-B2 Liquid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (US) 2016-05-10 US disclosed
WO-2016019013-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE PIONEER HI-BRED INTERNATIONAL, INC. (US) 2016-02-04 WO disclosed
US-8709513-B2 Liquid formulations of carboxamide arthropodicides E I DU PONT DE NEMOURS AND COMPANY (DE) 2014-04-29 US disclosed
US-20140005048-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E I DU PONT DE NEMOURS AND COMPANY (US) 2014-01-02 US disclosed
EP-2094092-B1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES DU PONT (US) 2012-10-31 EP disclosed
US-20110059846-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E. I. DU PONT DE NEMOURS AND COMPANY 2011-03-10 US disclosed
US-20100137374-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E.I. DUPONT DE NEMOURS AND COMPANY (US) 2010-06-03 US disclosed
US-20100055084-A1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 2010-03-04 US disclosed
EP-1968382-B1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES DU PONT (US) 2009-09-16 EP disclosed
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS ANNAN ISSAC BILLY 2009-03-19 US disclosed
US-20080305093-A1 Liquid Formulations of Carboxamide Arthropodicides FMC IP TECHNOLOGY GMBH (CH) 2008-12-11 US disclosed
WO-2008021152-A2 AGRONOMIC METHOD E. I. DU PONT DE NEMOURS AND COMPANY (US) 2008-02-21 WO disclosed
US-20070184018-A1 Anthranilamide insecticides E. I. DU PONT DE NEMOURS AND COMPANY 2007-08-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100137374-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, FAAH2, CNR2 TP53 4656/4885CNR1 4/4885CNR2 3/4885
US-20090076092-A1 METHOD FOR DISRUPTING REPRODUCTIVE PERFORMANCE OF ARTHROPODS NASP, CPS1, CYP11A1 TP53 4645/4885CNR1 332/4885CNR2 236/4885
US-20080305093-A1 Liquid Formulations of Carboxamide Arthropodicides FAAH, C9, FAAH2 TP53 3753/4885CNR1 15/4885CNR2 6/4885
US-20180168158-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 TP53 1822/4885CNR1 171/4885CNR2 68/4885
US-20070184018-A1 Anthranilamide insecticides F12, CBR3, F3 TP53 4207/4885CNR1 244/4885CNR2 180/4885
US-20100055084-A1 LIQUID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, CHIA, FAAH2 TP53 4711/4885CNR1 13/4885CNR2 7/4885
US-20140005048-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, CNR2, FAAH2 TP53 4723/4885CNR1 6/4885CNR2 2/4885
US-20110059846-A1 SOLID FORMULATIONS OF CARBOXAMIDE ARTHROPODICIDES FAAH, CNR2, FAAH2 TP53 4723/4885CNR1 6/4885CNR2 2/4885
US-20170215419-A1 ANTHRANILAMIDE SEED TREATMENT COMPOSITIONS AND METHODS OF USE AADAC, ABL2, API5 TP53 1822/4885CNR1 171/4885CNR2 68/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.