Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CCR1 | P32246 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TYR | P14679 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4162968 | 0.88 | LMNA (0.46) | ALKTP53LMNAHTTMAPT | |
| SCHEMBL18997523 | 0.85 | ALK (0.51) | ALKTP53PDK2LMNAHTT | |
| SCHEMBL19002642 | 0.85 | ACHE (0.52) | ALKTP53PDK2LMNAHTT | |
| SCHEMBL11294977 | 0.85 | CCR1 (0.46) | LMNAHTTMAPTALOX15L3MBTL1 | |
| SCHEMBL2205957 | 0.85 | CASP6 (0.59) | ALKLMNAMAPTCASP6GFER | |
| SCHEMBL13362096 | 0.85 | HTR1A (0.51) | LMNAHTTMAPTALOX15L3MBTL1 | |
| SCHEMBL1707770 | 0.85 | MAPT (0.57) | ALKPDK2LMNAMAPTALDH1A1 | |
| SCHEMBL4177069 | 0.84 | EGFR (0.46) | ALKTP53PDK2LMNAHTT | |
| SCHEMBL4174848 | 0.84 | L3MBTL1 (0.61) | ALKPDK2HTTMAPTL3MBTL1 | |
| SCHEMBL4172363 | 0.84 | MAPT (0.45) | ALKTP53LMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012061299-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2012-05-10 | — | — | WO | disclosed |