Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.61 |
| ▸ | NOS1 | P29475 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.61 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.61 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.61 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10339998 | 0.88 | ME2 (0.64) | NOS3NOS1SIGMAR1KCNH2KCNJ1 | |
| SCHEMBL25041411 | 0.86 | ALDH1A1 (0.75) | SIGMAR1HSD11B1MEN1KMT2ALMNA | |
| SCHEMBL6619237 | 0.84 | SLC6A3 (0.66) | SIGMAR1KCNH2MEN1KMT2A | |
| SCHEMBL4173376 | 0.84 | NOS3 (0.61) | NOS3NOS1SIGMAR1KCNH2KCNJ1 | |
| SCHEMBL10975702 | 0.80 | TSHR (0.71) | SIGMAR1HSD11B1MEN1KMT2ALMNA | |
| SCHEMBL10900913 | 0.79 | MEN1 (0.62) | SIGMAR1KCNH2MEN1KMT2A | |
| SCHEMBL4183633 | 0.79 | KDM4E (0.70) | NOS3NOS1SIGMAR1KCNH2HSD11B1 | |
| SCHEMBL10722408 | 0.79 | HSD11B1 (0.77) | HSD11B1MEN1KMT2ALMNAALDH1A1 | |
| SCHEMBL3967794 | 0.79 | HSD11B1 (0.77) | HSD11B1MEN1KMT2ALMNAALDH1A1 | |
| Hydrochloric Acid SCHEMBL10901273 | 0.79 | ALDH1A1 (0.60) | NOS3NOS1SIGMAR1KCNH2KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891332-B1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER (US) | 2004-03-17 | — | — | EP | disclosed |
| US-6465491-B2 | NITRIC OXIDE SYNTHASE INHIBITOR; NERVOUS SYSTEM DISORDERS | PFIZER INC. | 2002-10-15 | — | — | US | disclosed |
| US-20010034348-A1 | 6-phenylpyridyl-2-amine derivatives | LOWE JOHN A (US) | 2001-10-25 | — | — | US | disclosed |
| US-6235747-B1 | NITRIC OXIDE SYNTHASE INHIBITOR | PFIZER INC. | 2001-05-22 | — | — | US | disclosed |
| EP-0891332-A1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER INC. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036871-A1 | 6-PHENYLPYRIDYL-2-AMINE DERIVATIVES | PFIZER INC. (US) | 1997-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010034348-A1 | 6-phenylpyridyl-2-amine derivatives | NOS2, NOS3, NOS1 | NOS3 2/4885NOS1 3/4885SIGMAR1 696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.