Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2838991 | 0.83 | ALOX15 (0.36) | — | |
| SCHEMBL6970691 | 0.81 | KDM4E (0.32) | HDAC6 | |
| SCHEMBL2846342 | 0.80 | — | — | |
| SCHEMBL6967724 | 0.79 | — | — | |
| SCHEMBL6972428 | 0.78 | DRD2 (0.35) | — | |
| SCHEMBL6964458 | 0.78 | LMNA (0.43) | HDAC3HDAC6 | |
| SCHEMBL6966047 | 0.78 | ESR1 (0.37) | HDAC3NCOR2 | |
| SCHEMBL6957978 | 0.78 | SIRT1 (0.41) | — | |
| SCHEMBL6963063 | 0.77 | CYP3A4 (0.35) | — | |
| SCHEMBL6962637 | 0.77 | GAA (0.39) | HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008072061-A1 | METHOD OF TREATMENT OF OBESITY WITH AN MTP INHIBITOR IN CONJUNCTION WITH AN INCREASED-FAT DIET | PFIZER PRODUCTS INC. (US) | 2008-06-19 | — | — | WO | claimed |
| US-20090209492-A1 | Lipase Inhibitors | TRUSTEES OF TUFTS COLLEGE (US) | 2009-08-20 | — | — | US | disclosed |
| WO-2008072061-A1 | METHOD OF TREATMENT OF OBESITY WITH AN MTP INHIBITOR IN CONJUNCTION WITH AN INCREASED-FAT DIET | PFIZER PRODUCTS INC. (US) | 2008-06-19 | — | — | WO | disclosed |
| EP-1824861-A2 | LIPASE INHIBITORS | Trustees of the Tufts College (US) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006053250-A2 | LIPASE INHIBITORS | TRUSTEES OF TUFTS COLLEGE (US) | 2006-05-18 | — | — | WO | disclosed |
| EP-0902785-B1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID 2-(2H- 1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER (US) | 2002-09-04 | — | — | EP | disclosed |
| US-5998623-A | Process and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-a mide | PFIZER INC. (US) | 1999-12-07 | — | — | US | disclosed |
| EP-0902785-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID 2-(2H- 1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1999-03-24 | — | — | EP | disclosed |
| WO-1997041111-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID [2-(2H-[1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1997-11-06 | — | — | WO | disclosed |
| WO-1997041111-A1 | PROCESSES AND INTERMEDIATES FOR PREPARING 4'-TRIFLUOROMETHYLBIPHENYL-2-CARBOXYLIC ACID [2-(2H-[1,2,4]TRIAZOL-3-YLMETHYL)-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-6-YL]-AMIDE | PFIZER INC. (US) | 1997-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090209492-A1 | Lipase Inhibitors | LIPG, LPL, PNLIP | HDAC3 2563/4885HDAC6 2218/4885NCOR2 2196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.