Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | ATM | Q13315 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.56 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4367747 | 0.86 | L3MBTL1 (0.50) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL13883723 | 0.84 | L3MBTL1 (0.62) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL29466675 | 0.83 | L3MBTL1 (0.82) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL22319401 | 0.83 | L3MBTL1 (0.82) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL3650651 | 0.81 | MEN1 (0.69) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL4114974 | 0.81 | CTSD (0.69) | ALDH1A1GAAHPGDRAB9AMEN1 | |
| SCHEMBL6846935 | 0.81 | RAB9A (0.63) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL15334093 | 0.80 | PTGDR2 (0.53) | L3MBTL1NPSR1HPGDHTTRAB9A | |
| SCHEMBL16508287 | 0.80 | ALDH1A1 (0.58) | L3MBTL1NPSR1ALDH1A1GAAHPGD | |
| SCHEMBL16829424 | 0.80 | HCRTR1 (0.81) | L3MBTL1ALDH1A1GAAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074103-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | Exelixis, Inc. (US) | 2009-07-01 | — | — | EP | disclosed |
| WO-2008133955-A1 | 6-PHENYLPYRIMIDINONES AS PIM MODULATORS | EXELIXIS, INC. (US) | 2008-11-06 | — | — | WO | disclosed |
| US-6140352-A | FOR AGONIZING THE BETA 3 ADRENERGIC RECEPTOR TO TREAT TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY (US) | 2000-10-31 | — | — | US | disclosed |
| US-6093735-A | TREATMENT OF TYPE II DIABETES AND OBESITY | ELI LILLY AND COMPANY (US) | 2000-07-25 | — | — | US | disclosed |